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Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation
http://hdl.handle.net/10069/19133
http://hdl.handle.net/10069/191336d1259f6-db70-42be-94bf-009d5147d772
名前 / ファイル | ライセンス | アクション |
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RR45_1_105_110.pdf (566.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-12 | |||||
タイトル | ||||||
タイトル | Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ionizing radiation Genomic instability Normal human cells Telomere | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ojima, Mitsuaki
× Ojima, Mitsuaki× Hamano, Hiroki× Suzuki, Masatoshi× Suzuki, Keiji× Kodama, Seiji× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the delayed induction of telomere instability in hTERT-immortalized normal human fibroblast (BJl-hTERT) cells exposed to X-rays. BJl-hTERT cells were irradiated with 2 Gy of X-rays, and chromosome aberrations were analyzed 24 hours after irradiation and in the surviving cells 14 days after X-ray exposure. We found that the X-ray-surviving cells showed an increased frequency of chromatid gaps and breaks and chromosome fragments compared to the control cells. Furthermore, centromere- and telomere-FISH revealed that the frequency of telomere loss and duplication significantly increased in surviving cells compared to the control level. Because no induction of telomere abnormality was observed in cells 24 hours after irradiation, X-irradiation might not affect telomeres directly, but it specifically induces delayed telomere instability in normal human fibroblast cells. | |||||
書誌情報 |
Journal of radiation research 巻 45, 号 1, p. 105-110, 発行日 2004-03 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 2004, 45(1), p.105-110 |