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Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells
http://hdl.handle.net/10069/22222
http://hdl.handle.net/10069/222228671a983-0618-4d36-a55c-aef84fa88bf5
名前 / ファイル | ライセンス | アクション |
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EJH81_209.pdf (654.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-07 | |||||
タイトル | ||||||
タイトル | Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adult T-cell leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD25 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Foxp3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human T-cell leukemia virus type-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Treg | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Abe, Masaki
× Abe, Masaki× Uchihashi, Kinya× Tsuruda, Kazuto× Osaka, Akemi× Yanagihara, Katsunori× Hasegawa, Hiroo× Yamada, Yasuaki× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Foxp3 is a master gene of Treg cells, a novel subset of CD4+ T cells primarily expressing CD25. We describe here different features in Foxp3 expression profile between normal and leukemic CD4+CD25+ T cells, using peripheral blood samples from healthy controls (HCs), human T-cell leukemia virus type-1 (HTLV-1)-infected asymptomatic carriers (ACs), patients with adult T-cell leukemia (ATL), and various hematopoietic cell lines. The majority of CD4+CD25+ T cells in HCs were positive for Foxp3, but not all CD4+CD25+ T cells in ACs were positive, indicating that Foxp3 expression is not always linked to CD25 expression in normal T cells. Leukemic (ATL) T cells constitutively expressing CD25 were characteristic of heterogeneous Foxp3 expression, such as intra- and inter-case heterogeneity in intensity, inconsistency with CD25 expression, and a discrepancy in the mRNA and its protein expression. Surprisingly, a discernible amount of Foxp3 mRNA was detectable even in most cell lines without CD25 expression, a small fraction of which was positive for the Foxp3 proteins. The subcellular localization of Foxp3 in HTLV-1-infected cell lines was mainly cytoplasmic, different from that of primary ATL cells. These findings indicate that Foxp3 has two facets: essential Treg identity and molecular mimicry secondary to tumorigenesis. Conclusively, Foxp3 in normal T cells, but not mRNA, is basically potent at discriminating a subset of Treg cells from CD25 + T-cell populations, whereas the modulation of Foxp3 expression in leukemic T cells could be implicated in oncogenesis and has a potentially useful clinical role. | |||||
書誌情報 |
European Journal of Haematology 巻 81, 号 3, p. 209-217, 発行日 2008-09 |
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出版者 | ||||||
出版者 | Blackwell Publishing Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09024441 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10668976 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1600-0609.2008.01105.x | |||||
権利 | ||||||
権利情報 | (c) 2008 Blackwell Munksgaard | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Haematology, 81(3) pp.209-217; 2008 |