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Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease
http://hdl.handle.net/10069/16019
http://hdl.handle.net/10069/160191e500220-5d4a-4b06-836f-04634458bbae
名前 / ファイル | ライセンス | アクション |
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acta39_04_17_t.pdf (660.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BOOP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic eosinophilic pneumonia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Activated T cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Sawa, Hideaki
× Sawa, Hideaki× Kadota, Jun-Ichi× Kohno, Shigeru× Abe, Koh |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bronchiolitis obliterans organizing pneumonia (BOOP) is clinically and histologically difficult to differentiate from chronic eosinophilic pneumonia (CEP). The common histological feature of these diseases is an infiltration of mononuclear cells into the small airway, interstitial tissue and alveoli. Activation of T cells and secretion of lymphokines play a crucial role in the regulation and coordination of immune responses and inflammatory processes. In this study, we demonstrated the distribution of lymphocyte subpopulations and their stage of activation and T cellderived cytokine, IL-5 level in bronchoalveolar lavage (BAL) fluid obtained from patients with BOOP and CEP by comparison with sarcoidosis and diffuse panbronchiolitis (DPB). Flow cytometric analysis of T cell activation markers revealed that BOOP and sarcoidosis are characterized by increased absolute numbers of HLA-DR-bearing T cell subsets, while the relative numbers were increased in CEP and DPB. IL-5 in BAL fluids from BOOP and CEP was significantly high levels, and CEP patients with the high level of IL-5 showed the marked elevation of BAL eosinophils. Furthermor, it is of interest that the absolute numbers of HLA-DR T cells correlated with IL-5 levels in BAL fluid. These results suggest that activated T cells and secretion of IL-5 may be important factors in the pathogenetic processes of BOOP and CEP. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 95-100, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00095-P00100 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.95-100 |