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RBE-LET Relationships of High-LET Radiations in Drosophila Mutations
http://hdl.handle.net/10069/16843
http://hdl.handle.net/10069/16843b2316ea8-95d8-4eff-a7df-6a4feb9444e4
名前 / ファイル | ライセンス | アクション |
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jRR40_Supl_106.pdf (106.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-30 | |||||
タイトル | ||||||
タイトル | RBE-LET Relationships of High-LET Radiations in Drosophila Mutations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neutron | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Heavy ion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RBE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drosophila | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Somatic mutation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshikawa, Isao
× Yoshikawa, Isao× Takatsuji, Toshihiro× Nagano, Masaaki× Takada, Jun× Endo, Satoru× Hoshi, Masaharu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The relative biological effectiveness (RBE) of ^<252>Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results predominantly from mitotic crossing over induced in wing anlage cells of larvae, while the reverse mutation of eye-color is due to an intragenic structural change (2.96 kb-DNA excision) in the white locus on the X-chromosome. The measurements were performed in a combined mutation assay system so that induced mutant wing-hair clones as well as revertant eye-color clone can be detected simultaneously in the same individual. Larvae were irradiated at the age of 3 days post oviposition with ^<252>Cf neutrons, carbon beam or neon beam. For the neutron irradiation, the RBE values for wing-hair mutations were larger than that for eye-color mutation by about 7 fold. The RBE of carbon ions for producing the wing-hair mutations increased with increase in LET. The estimated RBE values were found to be in the range 2 to 6.5 for the wing-hair. For neon beam irradiation, the RBE values for wing-hair mutations peak near 150 keV/mm and decrease with further increase in LET. On the other hand, the RBE values for the induction of the eye-color mutation are nearly unity in ^<252>Cf neutrons and both ions throughout the LET range irradiated. We discuss the relationships between the initial DNA damage and LET in considering the mechanism of somatic mutation induction. | |||||
書誌情報 |
Journal of radiation research 巻 40, 号 Supl., p. 106-116, 発行日 1999-12 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 1999, 40(Supl.), p.106-116 |