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Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-1
http://hdl.handle.net/10069/37356
http://hdl.handle.net/10069/373566e89bccc-f78e-4e47-b852-4d793eed1391
名前 / ファイル | ライセンス | アクション |
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Onco7_71255.pdf (4.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-25 | |||||
タイトル | ||||||
タイトル | Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-1 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antiviral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endosome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gamma-interferon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Retroviruses | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thiolreductase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kubo, Yoshinao
× Kubo, Yoshinao× Izumida, Mai× Yashima, Yuka× Yoshii-Kamiyama, Haruka× Tanaka, Yuetsu× Yasui, Kiyoshi× Hayashi, Hideki× Matsuyama, Toshifumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mechanism by which type II interferon (IFN) inhibits virus replications remains to be identified. Murine leukemia virus (MLV) replication was significantly restricted by γ-IFN, but not human immunodeficiency virus type 1 (HIV-1) replication. Because MLV enters host cells via endosomes, we speculated that certain cellular factors among γ-IFN-induced, endosome-localized proteins inhibit MLV replication. We found that γ-IFN-inducible lysosomal thiolreductase (GILT) significantly restricts HIV- 1 replication as well as MLV replication by its thiolreductase activity. GILT silencing enhanced replication-defective HIV-1 vector infection and virion production in γ-IFNtreated cells, although γ-IFN did not inhibit HIV-1 replication. This result showed that GILT is required for the anti-viral activity of γ-IFN. Interestingly, GILT protein level was increased by γ-IFN in uninfected cells and env-deleted HIV-1-infected cells, but not in full-length HIV-1-infected cells. γ-IFN-induced transcription from the γ-IFNactivation sequence was attenuated by the HIV-1 Env protein. These results suggested that the γ-IFN cannot restrict HIV-1 replication due to the inhibition of γ-IFN signaling by HIV-1 Env. Finally, we found that 4,4'-dithiodipyridine (4-PDS), which inhibits S-S bond formation at acidic pH, significantly suppresses HIV-1 vector infection and virion production, like GILT. In conclusion, this study showed that GILT functions as a host restriction factor against the retroviruses, and a GILT mimic, 4-PDS, is the leading compound for the development of novel concept of anti-viral agents. | |||||
書誌情報 |
Oncotarget 巻 7, 号 44, p. 71255-71273, 発行日 2016-09-18 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19492553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.12104 | |||||
権利 | ||||||
権利情報 | c 2016 Impact Journals, LLC | |||||
権利 | ||||||
権利情報 | This article is licensed under a Creative Commons Attribution 3.0 License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncotarget, 7(44), pp.71255-71273; 2016 |