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Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin
http://hdl.handle.net/10069/4531
http://hdl.handle.net/10069/4531e9c43ac6-a2e1-445f-92d5-e2672146d9bd
名前 / ファイル | ライセンス | アクション |
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tm30_03_06_t.pdf (481.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yamashita, Kazunori
× Yamashita, Kazunori× Nonaka, Shigeo× Murayama, Fumio× Ohgami, Taro× Nagato, Nori× Irifune, Hiroko× Watanabe, Masahisa× Yoshida, Hikotaro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To investigate whether or not protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos^<[○!R]> HR/De strain mice for two to four months. Administration of GF caused protoporphyria in the hairless mice, that is, protoporphyrin levels in the erythrocytes and the liver were extremely elevated. Acute skin changes such as erythema, edema, blister and crust formation were produced by exposing the hairless mice with protoporphyria to 400 nm of light using the metal halide lamp. From these results, we confirmed that hairless mice of HR/De strain can be utilized as a model for protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes and are also convenient for photosensitivity experiments. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 30, 号 3, p. 219-224, 発行日 1988-09-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00219-P00224 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 30(3). p219-224, 1988 |