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Happy hypoxia in COVID-19 patients associated with hypoxic ventilatory depression
http://hdl.handle.net/10069/00041281
http://hdl.handle.net/10069/00041281104284e3-21e9-4952-a115-7c4e5c1ae97c
名前 / ファイル | ライセンス | アクション |
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ActMed65_73.pdf (463.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2022-02-25 | |||||
タイトル | ||||||
タイトル | Happy hypoxia in COVID-19 patients associated with hypoxic ventilatory depression | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | COVID-19 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypoxia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dyspnea | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ventilation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carotid body | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kimura, Hiroshi
× Kimura, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Acute exposure to hypoxia generally increase the ventilation. However, some of COVID-19 patients who suffer from pneumonia are characterized by hypoxic ventilatory depression with loss of dyspnea which is called as happy hypoxia. This report describes the background and the clinical issues of happy hypoxia. Methods: The mechanisms to increase ventilation and dyspnea under hypoxia are explained. Further, clinical issues and characteristics in COVID-19 are reviewed. Results: Genetic factors are definitely concerned with chemosensitivity to hypoxia. Further disease factors including COVID-19 infection could influence the attenuation of the chemosensitivity. This can be attributed to either ventilatory depression due to the modulation of metabolic substrate, adenosine in the brain, or autonomic neuropathy including the dysfunction of the carotid body. Conclusions: COVID-19 patients must be carefully treated and/or monitored to avoid hypoxic ventilator depression. The clinical application of aminophylline will be an issue to be considered. |
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書誌情報 |
Acta medica Nagasakiensia 巻 65, 号 2, p. 73-75, 発行日 2022-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
07 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 65(2), pp.73−75; 2022 |