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Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism
http://hdl.handle.net/10069/00041309
http://hdl.handle.net/10069/0004130918fb4d9d-a3fe-476c-b18f-6c9e60fa533a
名前 / ファイル | ライセンス | アクション |
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JCM11_1269.pdf (601.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-03-11 | |||||
タイトル | ||||||
タイトル | Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | triiodothyronine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroxine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | subclinical hypothyroidism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic kidney disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FT3/FT4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | euthyroid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | demand | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prevent | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Kawashiri, Shin-Ya× Noguchi, Yuko× Nakamichi, Seiko× Nagata, Yasuhiro× Hayashida, Naomi× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ratio of free triiodothyronine (FT3) to free thyroxine (FT4) (FT3/FT4), a maker of peripheral thyroxin deiodination, could indicate activity of thyroid hormone. Since positive association between subclinical hypothyroidism (SCH) and chronic kidney disease (CKD) was reported, clarifying the association among FT3/FT4, SCH, and CKD could be an efficient tool to make a strategy for preventing CKD. A cross-sectional study with 1724 Japanese with normal thyroid hormone was conducted. Significant positive association between SCH and CKD was observed; the adjusted odds ratio (OR) and 95% confidence interval (95% CI) was 2.23 (1.38, 3.59). Even though, FT3/FT4 was found to be inversely associated with CKD whereas positively associated with SCH; the adjusted ORs and 95% CIs for 1 standard deviation (SD) increment of FT3/FT4 were 0.51 (0.35, 0.74) for CKD and 2.40 (1.34, 4.29) for SCH, respectively. FT3/FT4 was also found to be positively associated with SCH without CKD but not those with CKD; 1 SD increment of FT3/FT4 were 3.44 (1.72, 6.91) for SCH without CKD and 1.11 (0.40, 3.06) for SCH with CKD, respectively. Although further investigation is necessary, present study indicates that higher activity of peripheral thyroxin deiodination might have beneficial association on absence of CKD even among SCH which is positively associated with CKD. | |||||
書誌情報 |
Journal of Clinical Medicine 巻 11, 号 5, p. 1269, 発行日 2022-02-25 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2077-0383 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/jcm11051269 | |||||
権利 | ||||||
権利情報 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Clinical Medicine, 11(5), art. no. 1269; 2022 |