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DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells
http://hdl.handle.net/10069/00042152
http://hdl.handle.net/10069/000421529df08b85-87a8-456f-8648-91dc2582877b
名前 / ファイル | ライセンス | アクション |
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II117_109913.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-03-30 | |||||
タイトル | ||||||
タイトル | DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer-associated fibroblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | C-X-C type chemokine ligand | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | C-X-C type chemokine receptor 2D | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ifferentiation-inducing factor-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor-associated macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor microenvironment | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Seto-Tetsuo, Fumi
× Seto-Tetsuo, Fumi× Arioka, Masaki× Miura, Koichi× Inoue, Takeru× Igawa, Kazunobu× Tomooka, Katsuhiko× Sasaguri, Toshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The tumor microenvironment (TME), largely composed of tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), plays a key role in cancer progression. A small molecule, differentiation-inducing factor-1 (DIF-1) secreted by Dictyostelium discoideum, is known to exhibit anticancer activity; however, its effect on the TME remains unknown. In this study, we investigated the effect of DIF-1 on the TME using mouse triple-negative breast cancer 4T1-GFP cells, mouse macrophage RAW 264.7 cells, and mouse primary dermal fibroblasts (DFBs). Polarization of 4T1 cell-conditioned medium-induced macrophage into TAMs was not affected by DIF-1. In contrast, DIF-1 decreased 4T1 cell co-culturing-induced C-X-C motif chemokine ligand 1 (CXCL1), CXCL5, and CXCL7 expression in DFBs and suppressed DFB differentiation into CAF-like cells. Additionally, DIF-1 inhibited C-X-C motif chemokine receptor 2 (CXCR2) expression in 4T1 cells. Immunohistochemical analyses of tumor tissue samples excised from breast cancer-bearing mice showed that DIF-1 did not affect the number of CD206-positive TAMs; however, it decreased the number of α-smooth muscle actin-positive CAFs and CXCR2 expression. These results indicated that the anticancer effect of DIF-1 was partially attributed to the inhibition of CXCLs/CXCR2 axis-mediated communication between breast cancer cells and CAFs. | |||||
書誌情報 |
International Immunopharmacology 巻 117, p. 109913, 発行日 2023-02-20 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15675769 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.intimp.2023.109913 | |||||
権利 | ||||||
権利情報 | ⓒ 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Immunopharmacology, 117, art. no. 109913; 2023 |