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Splenic CD11c(+) cells derived from semi-immune mice protect naive mice against experimental cerebral malaria
http://hdl.handle.net/10069/35277
http://hdl.handle.net/10069/352770c712428-0e58-490d-b226-664442bf200e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
MalJou14_23.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-05-08 | |||||
| タイトル | ||||||
| タイトル | Splenic CD11c(+) cells derived from semi-immune mice protect naive mice against experimental cerebral malaria | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD11c(+) DCs | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cerebral malaria | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Malaria-specific antibody | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Plasmacytoid DCs | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Semi-immune | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Bao, Lam Quoc
× Bao, Lam Quoc× Nhi, Dang M.× Huy, Nguyen Tien× Kikuchi, Mihoko× Yanagi, Tetsuo× Hamano, Shinjiro× Hirayama, Kenji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Immunity to malaria requires innate, adaptive immune responses and Plasmodium-specific memory cells. Previously, mice semi-immune to malaria was developed. Three cycles of infection and cure ('three-cure') were required to protect mice against Plasmodium berghei (ANKA strain) infection. Methods: C57BL/6 J mice underwent three cycles of P. berghei infection and drug-cure to become semi-immune. The spleens of infected semi-immune mice were collected for flow cytometry analysis. CD11c(+) cells of semiimmune mice were isolated and transferred into naive mice which were subsequently challenged and followed up by survival and parasitaemia. Results: The percentages of splenic CD4(+) and CD11c(+) cells were increased in semi-immune mice on day 7 post-infection. The proportion and number of B220(+)CD11c(+)low cells (plasmacytoid dendritic cells, DCs) was higher in semi-immune, three-cure mice than in their naive littermates on day 7 post-infection (2.6 vs 1.1% and 491,031 vs 149,699, respectively). In adoptive transfer experiment, three months after the third cured P. berghei infection, splenic CD11c(+) DCs of non-infected, semi-immune, three-cure mice slowed Plasmodium proliferation and decreased the death rate due to neurological pathology in recipient mice. In addition, anti-P. berghei IgG1 level was higher in mice transferred with CD11c(+) cells of semi-immune, three-cure mice than mice transferred with CD11c(+) cells of naive counterparts. Conclusion: CD11c(+) cells of semi-immune mice protect against experimental cerebral malaria three months after the third cured malaria, potentially through protective plasmacytoid DCs and enhanced production of malaria-specific antibody. | |||||
| 書誌情報 |
Malaria Journal 巻 14, p. 23, 発行日 2015-01-28 |
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| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14752875 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s12936-014-0533-y | |||||
| 権利 | ||||||
| 権利情報 | c 2015 Bao et al.; licensee Biomed Central. | |||||
| 権利 | ||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Malaria Journal, 14, 23; 2015 | |||||
