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Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation.
http://hdl.handle.net/10069/35821
http://hdl.handle.net/10069/358210bc00fc9-40bb-4079-81e5-da05b2685c4e
名前 / ファイル | ライセンス | アクション |
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ImpDen24_370.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-09-01 | |||||
タイトル | ||||||
タイトル | Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone formation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dental implant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human mesenchymal stem cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rabbit tibia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyahara, Kenji
× Miyahara, Kenji× Watamoto, Takao× Uto, Yusuke× Sawase, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: The aim of this study is to investigate the effect of macroscopic grooves on bone formation in vivo and differentiation of human mesenchymal stem cells (hMSCs) in vitro. Materials and Methods: The effects of macroscopic grooves on titanium alloy implants and disks were tested in rabbit tibiae and cultured hMSCs. The bone-to-implant contact (BIC) and bone area were evaluated in rabbit tibiae at 6 and 24 weeks after implant insertion. Osteoblastic differentiation was assessed by alkaline phosphatase (ALP) activity and real-time reverse-transcription polymerase chain reaction (RT-PCR) on days 7, 14, and 21. All values were statically analyzed. Results: BIC and bone area inside the grooves were significantly higher than those of control implants (P < 0.05). ALP activity was significantly higher for titanium disks with macroscopic grooves than without grooves on day 14 (P < 0.05). Real-time RT-PCR showed that the expression of osteogenic genes was significantly higher for disks with grooves on day 7 (P < 0.01). Conclusions: Macroscopic grooves accelerate osteoblastic differentiation in vitro and stimulate direct bone growth and deposition within the grooves in vivo. | |||||
書誌情報 |
Implant Dentistry 巻 24, 号 4, p. 370-376, 発行日 2015-08 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10566163 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/ID.0000000000000257 | |||||
権利 | ||||||
権利情報 | c 2015 Wolters Kluwer Health, Inc. | |||||
権利 | ||||||
権利情報 | This is a non-final version of an article published in final form in Implant Dentistry, 24(4), pp.370-376; 2015 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Implant Dentistry, 24(4), pp.370-376; 2015 |