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Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype
http://hdl.handle.net/10069/39666
http://hdl.handle.net/10069/396667d0d7b9a-a6c1-4fbe-b67b-6e8eaa618fd2
名前 / ファイル | ライセンス | アクション |
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Viruses12_12020169.pdf (3.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-19 | |||||
タイトル | ||||||
タイトル | Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CHIKV | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ECSA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | viral pathogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ngwe, Tun Mya Myat
× Ngwe, Tun Mya Myat× Muthugala, Rohitha× Kyaw, Kyaw Aung× Shimada, Satoshi× Morita, Kouichi× Hayasaka, Daisuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained. In this study, we examined the pathogenic potential of CHIKV ECSA genotype M-30 (M-30) by comparing it with that of African genotype S-27 (S-27) in mice. Following low titer infections in type-I IFN receptor KO (A129) mice, we found that the M-30 infection caused high and acute fatality compared with the S-27 infection. M-30-infected A129 mice showed higher viral loads in their central nervous systems and peripheral organs, and increased levels of IFN- responses in their brains. Interestingly, M-30-infected mice did not show the hypophagia and reductions in weight which were observed in S-27-infected mice. Our observations provide a novel explanation of the pathogenic mechanisms attributed to virus proliferation, anti-type-II IFN response and metabolic activity in the CHIKV ECSA virus in mice. | |||||
書誌情報 |
Viruses 巻 12, 号 2, p. 169, 発行日 2020-02-03 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19994915 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v12020169 | |||||
権利 | ||||||
権利情報 | c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Viruses, 12(2), art.no.169; 2020 |