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A bone substitute with high affinity for vitamin D-binding protein―relationship with niche of osteoclasts
http://hdl.handle.net/10069/34156
http://hdl.handle.net/10069/3415677c30ebe-23ed-4b55-b592-6d59ea90ab8b
名前 / ファイル | ライセンス | アクション |
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JCMM18_170.pdf (948.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-02-18 | |||||
タイトル | ||||||
タイトル | A bone substitute with high affinity for vitamin D-binding protein―relationship with niche of osteoclasts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydroxyapatite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophage activating factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoclast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Serum proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vitamin D-binding protein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Tohru
× Ikeda, Tohru× Kasai, Michiyuki× Tatsukawa, Eri× Kamitakahara, Masanobu× Shibata, Yasuaki× Yokoi, Taishi× Nemoto, Takayuki K.× Ioku, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The biological activity of osteoblasts and osteoclasts is regulated not only by hormones but also by local growth factors, which are expressed in neighbouring cells or included in bone matrix. Previously, we developed hydroxyapatite (HA) composed of rod-shaped particles using applied hydrothermal methods (HHA), and it revealed mild biodegradability and potent osteoclast homing activity. Here, we compared serum proteins adsorbed to HHA with those adsorbed to conventional HA composed of globular-shaped particles (CHA). The two ceramics adsorbed serum albumin and γ-globulin to similar extents, but affinity for γ-globulin was much greater than that to serum albumin. The chemotactic activity for macrophages of serum proteins adsorbed to HHA was significantly higher than that of serum proteins adsorbed to CHA. Quantitative proteomic analysis of adsorbed serum proteins revealed preferential binding of vitamin D-binding protein (DBP) and complements C3 and C4B with HHA. When implanted with the femur of 8-week-old rats, HHA contained significantly larger amount of DBP than CHA. The biological activity of DBP was analysed and it was found that the chemotactic activity for macrophages was weak. However, DBP-macrophage activating factor, which is generated by the digestion of sugar chains of DBP, stimulated osteoclastogenesis. These results confirm that the microstructure of hydroxyapatite largely affects the affinity for serum proteins, and suggest that DBP preferentially adsorbed to HA composed of rod-shaped particles influences its potent osteoclast homing activity and local bone metabolism. | |||||
書誌情報 |
Journal of Cellular and Molecular Medicine 巻 18, 号 1, p. 170-180, 発行日 2014-01 |
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出版者 | ||||||
出版者 | Blackwell Publishing | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15821838 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/jcmm.12180 | |||||
権利 | ||||||
権利情報 | c 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Cellular and Molecular Medicine, 18(1), pp.170-180; 2014 |