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A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction
http://hdl.handle.net/10069/34396
http://hdl.handle.net/10069/3439671ab9545-192b-49d1-aad6-2e05a9cd75a4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SciRep4_4517.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-05-21 | |||||
| タイトル | ||||||
| タイトル | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Chiba, Takuya
× Chiba, Takuya× Tamashiro, Yukari× Park, Daeui× Kusudo, Tatsuya× Fujie, Ryoko× Komatsu, Toshimitsu× Kim, Sang Eun× Park, Seongjoon× Hayashi, Hiroko× Mori, Ryoichi× Yamashita, Hitoshi× Chung, Hae Young× Shimokawa, Isao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy. | |||||
| 書誌情報 |
Scientific Reports 巻 4, p. 4517, 発行日 2014-03-31 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep04517 | |||||
| 権利 | ||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Scientific Reports, 4, 4517; 2014 | |||||
