WEKO3
アイテム
{"_buckets": {"deposit": "a9171d72-8b47-446c-8b28-6c8afdb31882"}, "_deposit": {"created_by": 2, "id": "599", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "599"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00000599", "sets": ["51"]}, "author_link": ["112164", "112162", "112166", "112163", "112165", "112168", "112167"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-12-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "61", "bibliographicPageStart": "54", "bibliographicVolumeNumber": "171", "bibliographic_titles": [{"bibliographic_title": "Toxicon"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We tested whether tetrodotoxin (TTX) functions as a stress relieving substance in puffer fish. We orally administered TTX to the juveniles of hatchery-reared non-toxic tiger puffer Takifugu rubripes and measured the effects of TTX on brain corticotropin-releasing hormone (CRH) mRNA expression and plasma cortisol levels in comparison with effects in non-toxic juveniles. Firstly, the reciprocal connections of CRH and adrenocorticotropic hormone (ACTH) were confirmed by dual-label immunohistochemistry. CRH-immunoreactive (ir) cell bodies were detected in the hypothalamus and CRH-ir fibers were observed to project to ACTH-ir cells in the rostral pars distalis of the pituitary. Next, a TTX-containing diet (2.35 mouse units (517?ng)/g diet) or a non-toxic diet were fed to the fish for 28 days under a recirculating system. Standard length and body weight became significantly larger in the TTX-treated group. The degree of loss of the caudal fin, which is an indicator of the degree of agonistic interactions, where high values show a higher loss of caudal fin of a fish due to nipping by other individuals, was significantly lower in the TTX-treated group. Relative CRH mRNA expression levels in the brain and cortisol levels in the plasma were significantly lower in the TTX-treated group. These results indicate that TTX functions as a stress relieving substance by affecting the CRH-ACTH-cortisol axis and reducing agonistic interactions in tiger puffer juveniles.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Toxicon, 171, pp.54-61; 2019", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Ltd."}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.toxicon.2019.09.024", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2019 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00410101", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Amano, Masafumi"}], "nameIdentifiers": [{"nameIdentifier": "112162", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amiya, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "112163", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takaoka, Minami"}], "nameIdentifiers": [{"nameIdentifier": "112164", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Haruka"}], "nameIdentifiers": [{"nameIdentifier": "112165", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takatani, Tomohiro"}], "nameIdentifiers": [{"nameIdentifier": "112166", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arakawa, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "112167", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakakura, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "112168", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Toxicon171_54.pdf", "filesize": [{"value": "601.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 601700.0, "url": {"label": "Toxicon171_54.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/599/files/Toxicon171_54.pdf"}, "version_id": "e9f7f095-1620-493f-bc33-39052e8fab30"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "TTX", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CRH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ACTH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cortisol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tiger puffer", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes"}]}, "item_type_id": "2", "owner": "2", "path": ["51"], "permalink_uri": "http://hdl.handle.net/10069/39769", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-09-30"}, "publish_date": "2020-09-30", "publish_status": "0", "recid": "599", "relation": {}, "relation_version_is_last": true, "title": ["Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes"], "weko_shared_id": -1}
Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes
http://hdl.handle.net/10069/39769
http://hdl.handle.net/10069/39769c5e4cc4c-ca17-41b4-b683-025ba85d8a06
名前 / ファイル | ライセンス | アクション |
---|---|---|
Toxicon171_54.pdf (601.7 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-09-30 | |||||
タイトル | ||||||
タイトル | Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TTX | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CRH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ACTH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cortisol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tiger puffer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Amano, Masafumi
× Amano, Masafumi× Amiya, Noriko× Takaoka, Minami× Sato, Haruka× Takatani, Tomohiro× Arakawa, Osamu× Sakakura, Yoshitaka |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We tested whether tetrodotoxin (TTX) functions as a stress relieving substance in puffer fish. We orally administered TTX to the juveniles of hatchery-reared non-toxic tiger puffer Takifugu rubripes and measured the effects of TTX on brain corticotropin-releasing hormone (CRH) mRNA expression and plasma cortisol levels in comparison with effects in non-toxic juveniles. Firstly, the reciprocal connections of CRH and adrenocorticotropic hormone (ACTH) were confirmed by dual-label immunohistochemistry. CRH-immunoreactive (ir) cell bodies were detected in the hypothalamus and CRH-ir fibers were observed to project to ACTH-ir cells in the rostral pars distalis of the pituitary. Next, a TTX-containing diet (2.35 mouse units (517?ng)/g diet) or a non-toxic diet were fed to the fish for 28 days under a recirculating system. Standard length and body weight became significantly larger in the TTX-treated group. The degree of loss of the caudal fin, which is an indicator of the degree of agonistic interactions, where high values show a higher loss of caudal fin of a fish due to nipping by other individuals, was significantly lower in the TTX-treated group. Relative CRH mRNA expression levels in the brain and cortisol levels in the plasma were significantly lower in the TTX-treated group. These results indicate that TTX functions as a stress relieving substance by affecting the CRH-ACTH-cortisol axis and reducing agonistic interactions in tiger puffer juveniles. | |||||
書誌情報 |
Toxicon 巻 171, p. 54-61, 発行日 2019-12-05 |
|||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00410101 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.toxicon.2019.09.024 | |||||
権利 | ||||||
権利情報 | c 2019 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Toxicon, 171, pp.54-61; 2019 |