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Proteomic profiling of antigens in circulating immune complexes associated with each of seven autoimmune diseases
http://hdl.handle.net/10069/35120
http://hdl.handle.net/10069/3512059ebe6d3-665a-4237-b660-3dbf37345f36
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Table S2.pdf (99.2 kB)
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Table S1.pdf (373.3 kB)
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CliBio48_181.pdf (143.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-03-10 | |||||
| タイトル | ||||||
| タイトル | Proteomic profiling of antigens in circulating immune complexes associated with each of seven autoimmune diseases | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Autoimmune disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immune complex | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immune complexome analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tandem mass spectrometry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ohyama, Kaname
× Ohyama, Kaname× Baba, Miyako× Tamai, Mami× Aibara, Nozomi× Ichinose, Kunihiro× Kishikawa, Naoya× Kawakami, Atsushi× Kuroda, Naotaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Immune complexes (ICs) trigger humoral immune responses. Therefore, the identification of constituent antigens within ICs would have very different clinical significance than identification of free antigens. Design and methods: Here, we applied immune complexome analysis of serum to the study of seven major autoimmune diseases-anti-neutrophil cytoplasmic antibody-associated vasculitis, Takayasu's arteritis, mixed connective tissue disease, dermatomyositis, Sjogren's syndrome, systemic scleroderma, and systemic lupus erythematosus-and healthy donors to comprehensively identify antigens incorporated into circulating ICs and to find disease-specific antigens. Results: We identified 468 distinct IC-associated antigens using this method. Importantly, 62 of those antigens were disease-specific antigens, and there were at least three disease-specific antigens for each of the seven autoimmune diseases. Of the disease-specific antigens identified, coiled-coil domain-containing protein 158 and spectrin were identified as potential autoantigens important to SSc and SS pathogenesis, respectively; notable titin and spectrin autoantibodies are reportedly found in SSc and SS patients, respectively. Conclusion: Immune complexome analysis may be generally applicable to the study of the relationship between ICs and autoimmune diseases in animals and humans. | |||||
| 書誌情報 |
Clinical Biochemistry 巻 48, 号 3, p. 181-185, 発行日 2015-02 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00099120 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.clinbiochem.2014.11.008 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. | |||||
| 権利 | ||||||
| 権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Biochemistry, 48, 3, (2015) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Clinical Biochemistry, 48(3), pp.181-185; 2015 | |||||
