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Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring
http://hdl.handle.net/10069/35124
http://hdl.handle.net/10069/35124e8eb437e-c67a-4046-a8d6-08e011f63661
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PhyBe130_40.pdf (308.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-03-18 | |||||
| タイトル | ||||||
| タイトル | Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Behavior | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Central nervous system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Genistein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Isoflavone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Non-monotonic dose response | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Perinatal exposure | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kohara, Yumi
× Kohara, Yumi× Kuwahara, Rika× Kawaguchi, Shinichiro× Jojima, Takeshi× Yamashita, Kimihiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10. mg/kg/day) or vehicle (1. ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality as assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory of rat offspring, but impaired their passive avoidance learning and memory. | |||||
| 書誌情報 |
Physiology & Behavior 巻 130, p. 40-46, 発行日 2014-05-10 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00319384 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.physbeh.2014.03.006 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 Elsevier Inc. | |||||
| 権利 | ||||||
| 権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Physiology & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Physiology & Behavior, 130, (2014) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Physiology & Behavior, 130, pp.40-46; 2014 | |||||
