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The expression of transporter OATP2/OATP8 decreases in undetectable hepatocellular carcinoma by Gd-EOB-MRI in the explanted cirrhotic liver
http://hdl.handle.net/10069/33436
http://hdl.handle.net/10069/33436fda3f134-b460-40c7-9a7b-3583311cf75c
名前 / ファイル | ライセンス | アクション |
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HepInt7_655.pdf (452.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-07-01 | |||||
タイトル | ||||||
タイトル | The expression of transporter OATP2/OATP8 decreases in undetectable hepatocellular carcinoma by Gd-EOB-MRI in the explanted cirrhotic liver | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EOB-MRI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatocellular carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | OATP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transporter | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hidaka, Masaaki
× Hidaka, Masaaki× Takatsuki, Mitsuhisa× Okudaira, Sadayuki× Soyama, Akihiko× Muraoka, Izumi× Tanaka, Takayuki× Yamaguchi, Izumi× Hara, Takanobu× Miyaaki, Hisamitsu× Ichikawa, Tatsuki× Hayashi, Tomayoshi× Sakamoto, Ichiro× Nakao, Kazuhiko× Kuroki, Tamotsu× Kanematsu, Takashi× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The aim of this study is to evaluate the detectability of hepatocellular carcinoma (HCC) in the explanted cirrhotic liver using gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) and the degree of organic anion transporter OATP2/OATP8 (OATP1B1/1B3) HCC which could not be preoperatively detected by multi-detector computed tomography (MD-CT) and Gd-EOB-MRI. Methods: Eleven patients (HBV 3, HCV 7, nonBnonC 1) out of 145 recipients of liver transplantation were analyzed. The detectability by each imaging modality and the expression of OATP2/OATP8 of HCC were analyzed using the whole liver thin sliced histological and immunohistochemical examination retrospectively. Results: The imaging examination detected 17 lesions of HCC by MDCT and/or Gd-EOB-MRI. Only one lesion detected by Gd-EOB-MRI had well differentiated and minute (7 mm) HCC. However, the histological examination revealed newly 11 lesions and one false-positive lesion of HCC in the explanted livers. The median diameter of the preoperatively undetectable HCC by imaging was 8 mm (2-12). The histological characteristic of the preoperatively undetectable HCC was well differentiated HCC (10/11). The accuracy rate in MDCT and Gd-EOB-MRI was 53.6 % (15/28) and 57.1 % (16/28). The rate of positive predictive value in MDCT and Gd-EOB-MRI was 93.7 % (15/16) and 94.2 % (16/17), respectively. The expression of OATP2/OATP8 in the preoperatively undetectable HCC was negative in nine lesions, was weak positive in two lesions. Conclusions: The detectability of Gd-EOB-MRI is almost equal to MDCT in a cirrhotic liver. Small HCCs were difficult to detect even with Gd-EOB-MRI. The transporter of OATP2/OATP8 was less expressed in the preoperatively undetectable HCCs. | |||||
書誌情報 |
Hepatology International 巻 7, 号 2, p. 655-661, 発行日 2013-06 |
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出版者 | ||||||
出版者 | Springer New York | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19360533 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19360541 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12072-012-9379-y | |||||
権利 | ||||||
権利情報 | © 2012 Asian Pacific Association for the Study of the Liver. | |||||
権利 | ||||||
権利情報 | The final publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hepatology International, 7(2), pp.655-661; 2013 |