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Phospholipid Membrane-Mediated Hemozoin Formation: The Effects of Physical Properties and Evidence of Membrane Surrounding Hemozoin
http://hdl.handle.net/10069/33766
http://hdl.handle.net/10069/337660d1dfb1f-a584-4eb2-88af-39cef0d4c673
名前 / ファイル | ライセンス | アクション |
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PLoS8_70025.pdf (4.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-09-20 | |||||
タイトル | ||||||
タイトル | Phospholipid Membrane-Mediated Hemozoin Formation: The Effects of Physical Properties and Evidence of Membrane Surrounding Hemozoin | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Huy, Nguyen Tien
× Huy, Nguyen Tien× Shima, Yusuke× Maeda, Atsushi× Men, Tran Thanh× Hirayama, Kenji× Hirase, Ai× Miyazawa, Atsuo× Kamei, Kaeko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Phospholipid membranes are thought to be one of the main inducers of hemozoin formation in Plasmodia and other blood-feeding parasites. The "membrane surrounding hemozoin" has been observed in infected cells but has not been observed in in vitro experiments. This study focused on observing the association of phospholipid membranes and synthetic β-hematin, which is chemically identical to hemozoin, and on a further exploration into the mechanism of phospholipid membrane-induced β-hematin formation. Our results showed that β-hematin formation was induced by phospholipids in the fluid phase but not in the gel phase. The ability of phospholipids to induce β-hematin formation was inversely correlated with gel-to-liquid phase transition temperatures, suggesting an essential insertion of heme into the hydrocarbon chains of the phospholipid membrane to form β-hematin. For this study, a cryogenic transmission electron microscope was used to achieve the first direct observation of the formation of a monolayer of phospholipid membrane surrounding β-hematin. | |||||
書誌情報 |
PLoS ONE 巻 8, 号 7, p. e70025, 発行日 2013-07-23 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0070025 | |||||
権利 | ||||||
権利情報 | © 2013 Huy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS ONE, 8(7), e70025; 2013 |