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Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats
http://hdl.handle.net/10069/34028
http://hdl.handle.net/10069/3402816bf691b-50b3-40be-8a80-b951404bfdfa
名前 / ファイル | ライセンス | アクション |
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JPS63_401.pdf (371.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-12-19 | |||||
タイトル | ||||||
タイトル | Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CGRP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypersensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immobilization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Spinal cord | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamaue, Yohei
× Hamaue, Yohei× Nakano, Jiro× Sekino, Yuki× Chuganji, Sayaka× Sakamoto, Jyunya× Yoshimura, Toshiro× Origuchi, Tomoki× Okita, Minoru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study examined mechanical and thermal hypersensitivity in the rat hind paw during cast immobilization of the hind limbs for 4 or 8 weeks and following cast removal. Blood flow, skin temperature, and volume of the rat hind paw were assessed in order to determine peripheral circulation of the hind limbs. Sensitization was analyzed by measuring the expression of the calcitonin gene-related peptide (CGRP) in the spinal dorsal horn following cast immobilization. Two weeks post immobilization, mechanical and thermal sensitivities increased significantly in all rats; however, peripheral circulation was not affected by immobilization. Cast immobilization for 8 weeks induced more serious hypersensitivity compared to cast immobilization for 4 weeks. Moreover, CGRP expression in the deeper lamina layer of the spinal dorsal horn increased in the rats immobilized for 8 weeks but not in those immobilized for 4 weeks. These findings suggest that immobilization-induced hypersensitivity develops during the immobilization period without affecting peripheral circulation. Our results also highlight the possibility that prolonged immobilization induces central sensitization in the spinal cord. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The final publication is available at link.springer.com | |||||
書誌情報 |
The Journal of Physiological Sciences 巻 63, 号 6, p. 401-408, 発行日 2013-11 |
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出版者 | ||||||
出版者 | 日本生理学会 | |||||
出版者別言語 | ||||||
Physiological Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18806546 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18806562 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12576-013-0277-4 | |||||
権利 | ||||||
権利情報 | © 2013 The Physiological Society of Japan and Springer Japan. | |||||
権利 | ||||||
権利情報 | The original publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of Physiological Sciences, 63(6), pp.401-408; 2013 |