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Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal
http://hdl.handle.net/10069/32434
http://hdl.handle.net/10069/324346eb7e41c-10b6-4fb0-8f24-7c881fe529ff
名前 / ファイル | ライセンス | アクション |
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DCB31_1636.pdf (564.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-24 | |||||
タイトル | ||||||
タイトル | Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kohno, Tomoko
× Kohno, Tomoko× Kubo, Yoshinao× Yasui, Kiyoshi× Haraguchi, Megumi× Shigematsu, Sayuri× Chua, Koon Jiew× Matsuyama, Toshifumi× Hayashi, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several cell stresses induce nuclear factor-kappaB (NF-κB) activation, which include irradiation, oxidation, and UV. Interestingly, serum-starving stress-induced NF-κB activation in COS cells, but not in COS-A717 cells. COSA717 is a mutant cell line of COS cells that is defective of the NF-κB signaling pathway. We isolated genes with compensating activity for the NF-κB pathway and one gene encoded the G protein b2 (Gb2). Gb2 is one of the G rotein-coupled receptor signaling effectors. In COS-A717 cells, Gb2 expression is significantly reduced. In Gb2 cDNA-transfected COS-A717 cells, the NF-κB activity was increased along with the recovery of Gb2 expression. Furthermore, serum-starving stress induced the NF-κB activity in Gb2-transfected COS-A717 cells. Consistently, the serum-starved COS cells with siRNA-reduced Gb2 protein expression showed decreased NF-κB activity. These results indicate that Gb2 is required for starvation-induced NF-κB activation and constitutive NF-kB activity. We propose that serum contains some molecule(s) that strongly inhibits NF-κB activation mediated through Gβ2 signaling. | |||||
書誌情報 |
DNA and Cell Biology 巻 31, 号 11, p. 1636-1644, 発行日 2012-11-01 |
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出版者 | ||||||
出版者 | Mary Ann Liebert Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10445498 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15577430 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1089/dna.2012.1666 | |||||
権利 | ||||||
権利情報 | This is a copy of an article published in the DNA and Cell Biology © 2012 Mary Ann Liebert, Inc.; DNA and Cell Biology is available online at: http://online.liebertpub.com. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | DNA and Cell Biology, 31(11), pp.1636-1644; 2012 |