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21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease
http://hdl.handle.net/10069/32730
http://hdl.handle.net/10069/3273059e51efe-a460-4440-933c-5e270c5b05f1
名前 / ファイル | ライセンス | アクション |
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HumImm74_783.pdf (393.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-10 | |||||
タイトル | ||||||
タイトル | 21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chagas disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human Leukocyte Antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 21-Hydroxylase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Haplotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Linkage | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
del, Puerto Florencia
× del, Puerto Florencia× Kikuchi, Mihoko× Nishizawa, Juan Eiki× Roca, Yelin× Avila, Cinthia× Gianella, Alberto× Lora, Javier× Gutierrez, Velarde Freddy Udalrico× Hirayama, Kenji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously reported protective haplotype HLA-B*14:02-DRB1*01:02 against chronic Chagas disease in Bolivia. The V281L mutant allele of the 21-Hydroxylase gene, CYP21A2*15, is reported to be located in the Class III region of the Human leukocyte antigen region and linked to the haplotype HLA-B*14:02-DRB1*01:02. The mutant allele might play a primary role in the pathogenesis of chronic Chagas disease in the associated HLA region. We analyzed the frequency of this allele in the same subjects for the previous one. The statistical analysis showed a significant association of the CYP21A2*15 with resistance to severe chronic Chagas disease (OR=0.207273; Pv=0.0041). However, there is no significant tendency of the mutant gene contribution to the resistance after the elimination of the HLA-B*14:02-DRB1*01:02 linked mutants (OR=0.38; Pv=0.1533). Although the frequency of the CYP21A2*15 was small, we found no primary contribution of this mutation to the protection against chronic Chagas disease. | |||||
書誌情報 |
Human Immunology 巻 74, 号 6, p. 783-786, 発行日 2013-06 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01988859 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.humimm.2013.01.023 | |||||
権利 | ||||||
権利情報 | © 2013 American Society for Histocompatibility and Immunogenetics | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Human Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Human Immunology, 74, 6(2013) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human Immunology, 74(6), pp.783-786; 2013 |