| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2012-06-22 |
| タイトル |
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|
タイトル |
Clinical and molecular analysis of synchronous double lung cancers |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Synchronous double cancers |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Intrapulmonary metastasis |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Non small cell lung cancer |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Array comparative genomic hybridization |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Epidermal growth factor receptor |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Diagnosis |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Prognosis |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Arai, Junichi
Tsuchiya, Tomoshi
Oikawa, Masahiro
Mochinaga, Koji
Hayashi, Tomayoshi
Yoshiura, Koh-ichiro
Tsukamoto, Kazuhiro
Yamasaki, Naoya
Matsumoto, Keitaro
Miyazaki, Takuro
Nagayasu, Takeshi
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Since multiple lung cancer treatment strategies differ, it is essential for clinicians to be able to distinguish between separate primary lesions and metastasis. In the present study, we used array comparative genomic hybridization (aCGH) and somatic mutation (epidermal growth factor receptor: EGFR) to analyze genomic alteration profiles in lung cancer patients. To validate the consistency among the pathological assessments and clarify the clinical differences between double primary lesions and metastasis, we also examined synchronous double lung cancer clinical data. Methods: Between January 1970 and March 2010, 2215 patients with lung cancer underwent surgical resection at Nagasaki University Hospital. We performed molecular analysis of 12 synchronous double lung cancer patients without lymph node metastasis (intrapulmonary metastasis in the same lobe (pm1): n = 6, primary: n = 6). We then evaluated the clinical outcomes of patients with pathologically diagnosed synchronous double lung cancers (intrapulmonary metastasis (pm): n = 80, primary: n = 39) and other T3 tumors (n = 230). Results: Examination of the concordance rate (CR) of the copy number changes (CNCs) for paired tumors showed that the metastasis group was larger than the primary group (55.5% vs. 19.6%, p = 0.04). Pathological diagnosis and molecular classification were the same in 10 out of 12 cases (83%). As compared to the primary group, there tended to be an inferior 5-year survival curve for the pm group. However, in N0 patients, the survival curve for the pm group overlapped the primary group, while the survival rate of the pm1 group was much higher than that of other T3 group (p < 0.01). Conclusions: Both pathological and molecular assessment using aCGH adapted in the current study appeared to have a consistency. Pathological pm1(T3)N0 patients may have a better prognosis than other T3N0 patients. |
| 書誌情報 |
Lung Cancer
巻 77,
号 2,
p. 281-287,
発行日 2012
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| 出版者 |
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出版者 |
Elsevier Ireland Ltd |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
01695002 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11536857 |
| DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.lungcan.2012.04.003 |
| 権利 |
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|
権利情報 |
NOTICE: this is the author’s version of a work that was accepted for publication in Lung Cancer. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Lung Cancer, 77, 2(2012) |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関係URI |
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関連名称 |
http://hdl.handle.net/10069/32638 |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Lung Cancer, 77(2), pp.281-287; 2012 |
LunCan77_281.pdf (2.5 MB)
