WEKO3
アイテム
{"_buckets": {"deposit": "499994e0-c462-4689-957c-5986e7c28f10"}, "_deposit": {"created_by": 2, "id": "10486", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "10486"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00010486", "sets": ["36"]}, "author_link": ["41645", "41642", "41643", "41651", "41648", "41647", "41652", "41653", "41650", "41649", "41646", "41641", "41644", "41640", "41639"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-02-21", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageStart": "e1505", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "PLoS Neglected Tropical Diseases"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Recent in-vitro studies have suggested that mast cells are involved in Dengue virus infection. To clarify the role of mast cells in the development of clinical Dengue fever, we compared the plasma levels of several mast cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) and -related cytokines (IL-4, -9, and -17) between patients with differing severity of Dengue fever and healthy controls. Methodology/Principal Findings: The study was performed at Children\u0027s Hospital No. 2, Ho Chi Minh City, and Vinh Long Province Hospital, Vietnam from 2002 to 2005. Study patients included 103 with Dengue fever (DF), Dengue hemorrhagic fever (DHF), and Dengue shock syndrome (DSS), as diagnosed by the World Health Organization criteria. There were 189 healthy subjects, and 19 febrile illness patients of the same Kinh ethnicity. The levels of mast cell-derived mediators and -related cytokines in plasma were measured by ELISA. VEGF and sVEGFR-1 levels were significantly increased in DHF and DSS compared with those of DF and controls, whereas sVEGFR-2 levels were significantly decreased in DHF and DSS. Significant increases in tryptase and chymase levels, which were accompanied by high IL-9 and -17 concentrations, were detected in DHF and DSS patients. By day 4 of admission, VEGF, sVEGFRs, and proteases levels had returned to similar levels as DF and controls. In-vitro VEGF production by mast cells was examined in KU812 and HMC-1 cells, and was found to be highest when the cells were inoculated with Dengue virus and human Dengue virus-immune serum in the presence of IL-9. Conclusions: As mast cells are an important source of VEGF, tryptase, and chymase, our findings suggest that mast cell activation and mast cell-derived mediators participate in the development of DHF. The two proteases, particularly chymase, might serve as good predictive markers of Dengue disease severity.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "PLoS Neglected Tropical Diseases, 6(2), e1505; 2012", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1371/journal.pntd.0001505", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012 Furuta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "19352735", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Furuta, Takahisa"}], "nameIdentifiers": [{"nameIdentifier": "41639", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murao, Lyre Anni"}], "nameIdentifiers": [{"nameIdentifier": "41640", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lan, Nguyen Thi Phuong"}], "nameIdentifiers": [{"nameIdentifier": "41641", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Huy, Nguyen Tien"}], "nameIdentifiers": [{"nameIdentifier": "41642", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Huong, Vu Thi Que"}], "nameIdentifiers": [{"nameIdentifier": "41643", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Thuy, Tran Thi"}], "nameIdentifiers": [{"nameIdentifier": "41644", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tham, Vo Dinh"}], "nameIdentifiers": [{"nameIdentifier": "41645", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nga, Cao Thi Phi"}], "nameIdentifiers": [{"nameIdentifier": "41646", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ha, Tran Thi Ngoc"}], "nameIdentifiers": [{"nameIdentifier": "41647", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohmoto, Yasukazu"}], "nameIdentifiers": [{"nameIdentifier": "41648", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Mihoko"}], "nameIdentifiers": [{"nameIdentifier": "41649", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Kouichi"}], "nameIdentifiers": [{"nameIdentifier": "41650", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasunami, Michio"}], "nameIdentifiers": [{"nameIdentifier": "41651", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "41652", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Naohiro"}], "nameIdentifiers": [{"nameIdentifier": "41653", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PLoSNeg6_1505.pdf", "filesize": [{"value": "532.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 532500.0, "url": {"label": "PLoSNeg6_1505.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/10486/files/PLoSNeg6_1505.pdf"}, "version_id": "0caff359-6cc0-4e8e-8ce3-b239f69843aa"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association of mast cell-derived VEGF and proteases in dengue shock syndrome", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association of mast cell-derived VEGF and proteases in dengue shock syndrome"}]}, "item_type_id": "2", "owner": "2", "path": ["36"], "permalink_uri": "http://hdl.handle.net/10069/28990", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-08-09"}, "publish_date": "2012-08-09", "publish_status": "0", "recid": "10486", "relation": {}, "relation_version_is_last": true, "title": ["Association of mast cell-derived VEGF and proteases in dengue shock syndrome"], "weko_shared_id": -1}
Association of mast cell-derived VEGF and proteases in dengue shock syndrome
http://hdl.handle.net/10069/28990
http://hdl.handle.net/10069/289905b246b4e-9aec-4ae5-af07-9ace9e4e4dd5
名前 / ファイル | ライセンス | アクション |
---|---|---|
PLoSNeg6_1505.pdf (532.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-08-09 | |||||
タイトル | ||||||
タイトル | Association of mast cell-derived VEGF and proteases in dengue shock syndrome | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Furuta, Takahisa
× Furuta, Takahisa× Murao, Lyre Anni× Lan, Nguyen Thi Phuong× Huy, Nguyen Tien× Huong, Vu Thi Que× Thuy, Tran Thi× Tham, Vo Dinh× Nga, Cao Thi Phi× Ha, Tran Thi Ngoc× Ohmoto, Yasukazu× Kikuchi, Mihoko× Morita, Kouichi× Yasunami, Michio× Hirayama, Kenji× Watanabe, Naohiro |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Recent in-vitro studies have suggested that mast cells are involved in Dengue virus infection. To clarify the role of mast cells in the development of clinical Dengue fever, we compared the plasma levels of several mast cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) and -related cytokines (IL-4, -9, and -17) between patients with differing severity of Dengue fever and healthy controls. Methodology/Principal Findings: The study was performed at Children's Hospital No. 2, Ho Chi Minh City, and Vinh Long Province Hospital, Vietnam from 2002 to 2005. Study patients included 103 with Dengue fever (DF), Dengue hemorrhagic fever (DHF), and Dengue shock syndrome (DSS), as diagnosed by the World Health Organization criteria. There were 189 healthy subjects, and 19 febrile illness patients of the same Kinh ethnicity. The levels of mast cell-derived mediators and -related cytokines in plasma were measured by ELISA. VEGF and sVEGFR-1 levels were significantly increased in DHF and DSS compared with those of DF and controls, whereas sVEGFR-2 levels were significantly decreased in DHF and DSS. Significant increases in tryptase and chymase levels, which were accompanied by high IL-9 and -17 concentrations, were detected in DHF and DSS patients. By day 4 of admission, VEGF, sVEGFRs, and proteases levels had returned to similar levels as DF and controls. In-vitro VEGF production by mast cells was examined in KU812 and HMC-1 cells, and was found to be highest when the cells were inoculated with Dengue virus and human Dengue virus-immune serum in the presence of IL-9. Conclusions: As mast cells are an important source of VEGF, tryptase, and chymase, our findings suggest that mast cell activation and mast cell-derived mediators participate in the development of DHF. The two proteases, particularly chymase, might serve as good predictive markers of Dengue disease severity. | |||||
書誌情報 |
PLoS Neglected Tropical Diseases 巻 6, 号 2, p. e1505, 発行日 2012-02-21 |
|||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19352735 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pntd.0001505 | |||||
権利 | ||||||
権利情報 | © 2012 Furuta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS Neglected Tropical Diseases, 6(2), e1505; 2012 |