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Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice
http://hdl.handle.net/10069/29148
http://hdl.handle.net/10069/291480cb89bc2-68a2-4c5a-bf43-8717b1c6b43b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CTR348_81.pdf (9.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-03 | |||||
| タイトル | ||||||
| タイトル | Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | BALB/c | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | C57BL/6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ddY | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Differentiation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteoclasts | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Narahara, Shun
× Narahara, Shun× Matsushima, Haruna× Sakai, Eiko× Fukuma, Yutaka× Nishishita, Kazuhisa× Okamoto, Kuniaki× Tsukuba, Takayuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Osteoclasts (OCLs) are multinucleated giant cells and are formed by the fusion of mononuclear progenitors of monocyte/macrophage lineage. It is known that macrophages derived from different genetic backgrounds exhibit quite distinct characteristics of immune responses. However, it is unknown whether OCLs from different genetic backgrounds show distinct characteristics. In this study, we showed that bone-marrow macrophages (BMMs) derived from C57BL/6, BALB/c and ddY mice exhibited considerably distinct morphological characteristics and cell differentiation into OCLs. The differentiation of BMMs into OCLs was comparatively quicker in the C57BL/6 and ddY mice, while that of BALB/c mice was rather slow. Morphologically, ddY OCLs showed a giant cell with a round shape, C57BL/6 OCLs were of a moderate size with many protrusions and BALB/c OCLs had the smallest size with fewer nuclei. The intracellular signaling of differentiation and expression levels of marker proteins of OCLs were different in the respective strains. Treatment of BMMs from the three different strains with the reducing agent N-acetylcysteine (NAC) or with the oxidation agent hydrogen peroxide (H 2O 2) induced changes in the shape and sizes of the cells and caused distinct patterns of cell differentiation and survival. Thus, genetic backgrounds and redox conditions regulate the morphological characteristics and cell differentiation of OCLs. | |||||
| 書誌情報 |
Cell and Tissue Research 巻 348, 号 1, p. 81-94, 発行日 2012-04 |
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| 出版者 | ||||||
| 出版者 | Springer Verlag | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0302766X | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14320878 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00441-012-1325-8 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Springer-Verlag. | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at www.springerlink.com. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Cell and Tissue Research, 348 (1), pp. 81-94; 2012 | |||||
