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Formation and Conformation of Baicalin–Berberine and Wogonoside–Berberine Complexes
http://hdl.handle.net/10069/29407
http://hdl.handle.net/10069/2940746966ba8-3597-4a3b-9a15-233488d41df2
名前 / ファイル | ライセンス | アクション |
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CPBul60_706.pdf (823.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-09 | |||||
タイトル | ||||||
タイトル | Formation and Conformation of Baicalin–Berberine and Wogonoside–Berberine Complexes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Baicalin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Baicalin-berberine complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Berberine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ionic interaction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wogonoside | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Rong, Wang Jing
× Rong, Wang Jing× Tanaka, Takashi× Zhang, Hong× Kouno, Isao× Hong, Jiang Zhi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is well-known that baicalin–berberine complex (1) precipitates in the water decoction of numerous Chinese Medicinal formulae containing Radix Scutellariae and Rhizoma Coptidis or Cortex Phellodendri. In the current study, ionic interaction between the carboxylate ion of baicalin and the quaternary ammonium ion of berberine was revealed to be responsible for the formation of 1 and wogonoside–berberine (2) by using FAB-MS and NMR titration experiments. In addition, nuclear Overhauser effect spectroscopy (NOESY) correlations observed in 1 and 2 suggested quite different conformation of the two complexes, which was further supported by the fact that the [α]D of the canadine obtained by reduction of 1 is of an opposite sign to that obtained from 2. Partition coefficients (n-octanol/water) determination demonstrated 12–20 times larger partition coefficient of each complex (1, 2) than that of each single compound (baicalin, wogonoside, and berberine), indicating the significant role of the formation of the complex in the bioavailability enhancement of these pharmacologically active constituents. | |||||
書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 60, 号 6, p. 706-711, 発行日 2012-06-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
The Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092363 | |||||
権利 | ||||||
権利情報 | © 2012 The Pharmaceutical Society of Japan. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical and Pharmaceutical Bulletin, 60(6), pp.706-711; 2012 |