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Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients
http://hdl.handle.net/10069/38578
http://hdl.handle.net/10069/385786e795de9-772d-4174-a77c-0d21b5140ef5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK1091_Suehiro.pdf (831.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-19 | |||||
| タイトル | ||||||
| タイトル | Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chemoembolization | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | therapeutic | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | exosome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microRNA | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
末廣, 智之
× 末廣, 智之 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 116160 | |||||
| 姓名 | Suehiro, Tomoyuki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR?122 and miR?21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy?five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR?122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR?21 expression levels did not significantly change. The expression levels of exosomal miR?122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child?Pugh score (r=?0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease?specific survival. According to the median relative expression of miR?122 after TACE/before TACE (miR?122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR?122 ratio had significantly longer disease?specific survival, compared with that of the patients with the lower miR?122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR?122 ratio (HR 2.720; 95% confidence interval, 1.035?8.022; P=0.042) is associated with the disease?specific survival. Taken together, our results demonstrate that the exosomal miR?122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1091号 学位授与年月日:平成30年9月5日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Tomoyuki Suehiro, Hisamitsu Miyaaki, Yasuko Kanda, Hidetaka Shibata, Takuya Honda, Eisuke Ozawa, Satoshi Miuma, Naota Taura, Kazuhiko Nakao | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Oncology Letters, 16(3), pp.3267-3273; 2018 | |||||
| 書誌情報 |
Oncology Letters 巻 16, 号 3, p. 3267-3273, 発行日 2018-09-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17921074 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17921082 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/ol.2018.8991 | |||||
| 権利 | ||||||
| 権利情報 | c 2018, Spandidos Publications | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 経動脈的化学塞栓術を行った肝細胞癌患者のバイオマーカーとしての血清中のexosomal microRNA-122およびmicroRNA-21の意義 | |||||
| 出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-09-05 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第1091号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2018-09-05) | |||||
