WEKO3
アイテム
Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
http://hdl.handle.net/10069/25484
http://hdl.handle.net/10069/254843f7335fb-a73d-491b-bae1-dd1aa7dfaf1a
名前 / ファイル | ライセンス | アクション |
---|---|---|
JRR52_369.pdf (379.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-08-08 | |||||
タイトル | ||||||
タイトル | Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Norepinephrine (NE) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat ileal epithelial cells (IEC-18) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuu-Matsuyama, Mutsumi
× Matsuu-Matsuyama, Mutsumi× Okaichi, Kumio× Shichijo, Kazuko× Nakayama, Toshiyuki× Nakashima, Masahiro× Sekine, Ichiro |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously reported that the apoptosis index in jejunal crypt cells after X irradiation was greater in spontaneously hypertensive rats than in Wistar-Kyoto rats. Moreover, these same cells showed a suppression of apoptosis when reserpine was administered to induce sympathetic dysfunction in spontaneously hypertensive rats or Wistar-Kyoto rats.1) Whether the hyperfunction of the sympathetic nervous system is involved in the high susceptibility of the jejunal crypt cells to radiation-induced apoptosis was the subject of this study. The effect of norepinephrine (NE) on cell survival was examined using the colony formation assay after X-ray irradiation of rat ileal epithelial cells (IEC-18). The addition of 1 μM NE decreased the surviving fraction of cells irradiated with 6 Gy from 37% to 8%. The radiosensitivity of IEC-18 cells was enhanced by the addition of 1 μM of NE. The irradiation and treatment with NE also resulted in an increased cellular apoptotic rate. These results showing enhanced radiosensitivity of rat ileal epithelial cells by NE suggest that NE may be one of the factors which aggravate acute radiation injury in the intestine. | |||||
書誌情報 |
Journal of Radiation Research 巻 52, 号 3, p. 369-373, 発行日 2011-05-31 |
|||||
出版者 | ||||||
出版者 | Journal of Radiation Research Editorial Committee | |||||
出版者別言語 | ||||||
値 | 日本放射能影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1269/jrr.10155 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2011 by Journal of Radiation Research Editorial Committee | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Radiation Research, 52(3), pp.369-373; 2011 |