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Serotonin Receptors are Involved in the Vagal Afferent Transmission of Exogenous Ghrelin-Evoked Appetite Sensation Mediated Though C-Fibers
http://hdl.handle.net/10069/24157
http://hdl.handle.net/10069/24157006d9693-4454-49b0-b90d-e3895adae07b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ActaMed55_15.pdf (205.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2010-10-08 | |||||
| タイトル | ||||||
| タイトル | Serotonin Receptors are Involved in the Vagal Afferent Transmission of Exogenous Ghrelin-Evoked Appetite Sensation Mediated Though C-Fibers | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Afferent vagus nerves | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Capsaicin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Food intake | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Type-3 serotonin receptors | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Matsunaga, Tomoe
× Matsunaga, Tomoe |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ghrelin, an endogenous appetite hormone, is secreted from the gastro-intestinal tract, and the ghrelin-induced appetite is conveyed through the afferent vagus nerves. However, it has not been elucidated how the orexigenic sensation produced by ghrelin is transmitted to the afferent vagus nerves that innervate gastro-intestinal tract. To address this issue, ghrelin-induced food intake in Wister rats was evaluated in the presence or absence of vagal denervation or the administration of a type-3 serotonin receptor antagonist ramosetoron. Cumulative food intake was significantly increased 1 hr and 2 hr after the intraperitoneally-applied ghrelin (20μg/kg). Desensitization of C-fiber of the afferent vagus nerves by intraperitoneally-applied capsaicin completely abolished the increases in the ghrelin-induced food intake. Surgical vagotomy of the hepatic or gastric branches markedly suppressed the ghrelin-evoked feeding. Furthermore, pretreatment with ramosetoron also significantly suppressed the ghrelin-evoked feeding. Stimulatory effects of ghrelin on the appetite were transient and the overall food intake was comparable after 24 hr among all groups. These data suggest that 1) exogenous ghrelin rapidly promotes feeding, but such feeding lasts no more than 2 hr; 2) afferent C-fiber of the hepatic or gastric vagus nerves appear to convey ghrelininduced hungry sensation to the brain; 3) type-3 serotonin receptors at the nerve endings of the C-fiber of the gastric or hepatic afferent vagus nerves may involve in transmitting the ghrelin-evoked hungry sensation. | |||||
| 書誌情報 |
Acta Medica Nagasakiensia 巻 55, 号 1, p. 15-21, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Nagasaki University School of Medicine | |||||
| 出版者別言語 | ||||||
| 値 | 長崎大学医学部 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta Medica Nagasakiensia, 55(1), pp.15-21; 2010 | |||||
