| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-10-03 |
| タイトル |
|
|
タイトル |
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia. |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Legionella pneumophila |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neutrophil elastase severe pneumonia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Morinaga, Yoshitomo
Yanagihara, Katsunori
Araki, Nobuko
Yamada, Koichi
Seki, Masafumi
Izumikawa, Koichi
Kakeya, Hiroshi
Yamamoto, Yoshihiro
Yamada, Yasuaki
Kohno, Shigeru
Kamihira, Shimeru
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
It is important to regulate excessive inflammation when patients with severe infectious disease are treated. Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. The combination therapy did not show a significant survival improvement compared to the treatment with fluoroquinolone alone, but reduced bacteria number and inflammatory cells in the early phase. The combination therapy can contribute to treatment of L. pneumophila pneumonia with protecting lungs. |
| 書誌情報 |
Experimental lung research
巻 36,
号 8,
p. 484-490,
発行日 2010-10
|
| 出版者 |
|
|
出版者 |
Informa Healthcare USA, Inc. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01902148 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15210499 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00181680 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
20939755 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3109/01902141003728874 |
| 権利 |
|
|
権利情報 |
© 2010 Informa Healthcare USA, Inc. |
| 権利 |
|
|
権利情報 |
This is an electronic version of an article published in Experimental lung research, 36(8), pp.484-490; 2010. Experimental lung research is available online at: http://www.informaworld.com/openurl?genre=article&id=doi:10.3109/01902141003728874. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Experimental lung research, 36(8), pp.484-490; 2010 |
ELR36_484.pdf (358.4 kB)
