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Our objective was to evaluate the association of BMI with blood folate and total homocysteine (tHcy) concentrations. METHODS: We measured plasma and erythrocyte folate and plasma tHcy concentrations in 434 healthy adults (343 women and 91 men; mean age of 63.8 ± 10.7 [SD, range 23-88] years), who participated in a 2007 population-based survey in western Japan. RESULTS: The overall mean plasma and erythrocyte folate and tHcy were 21.6 (±11.0, SD) nmol/L, 844 (±291) nmol/L and 11.6 (±3.9) μmol/L, respectively. The mean BMI was 22.8 (±3.0; 15.6-33.3) kg/m(2), and only 72 subjects (17%) had BMI \u003e 26.0 kg/m(2). Mean plasma folate decreased as BMI increased (p-trend \u003c 0.01), whereas mean erythrocyte folate and plasma tHcy were similar regardless of BMI (p-trends = 0.49 and 0.28, respectively). CONCLUSION: Our data indicate that the interpretation of plasma folate concentrations to assess folate nutritional status is complicated by BMI, although the impact of BMI on plasma folate was relatively small. It is important to take this association into account for the selection of subjects for future large-scale studies. 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Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults.
http://hdl.handle.net/10069/24792
http://hdl.handle.net/10069/247928232bfd1-463e-4410-be3a-b912d6212fa0
名前 / ファイル | ライセンス | アクション |
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EJN_Nakazato.pdf (120.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-03-25 | |||||
タイトル | ||||||
タイトル | Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blood | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Body mass index | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Folate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Homocysteine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakazato, Mio
× Nakazato, Mio× Maeda, Takahiro× Takamura, Noboru× Wada, Mitsuhiro× Yamasaki, Hironori× Johnston, Kelley E× Tamura, Tsunenobu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: Plasma folate concentrations are suggested to be negatively associated with body mass index (BMI, kg/m(2)), although these findings are controversial. Our objective was to evaluate the association of BMI with blood folate and total homocysteine (tHcy) concentrations. METHODS: We measured plasma and erythrocyte folate and plasma tHcy concentrations in 434 healthy adults (343 women and 91 men; mean age of 63.8 ± 10.7 [SD, range 23-88] years), who participated in a 2007 population-based survey in western Japan. RESULTS: The overall mean plasma and erythrocyte folate and tHcy were 21.6 (±11.0, SD) nmol/L, 844 (±291) nmol/L and 11.6 (±3.9) μmol/L, respectively. The mean BMI was 22.8 (±3.0; 15.6-33.3) kg/m(2), and only 72 subjects (17%) had BMI > 26.0 kg/m(2). Mean plasma folate decreased as BMI increased (p-trend < 0.01), whereas mean erythrocyte folate and plasma tHcy were similar regardless of BMI (p-trends = 0.49 and 0.28, respectively). CONCLUSION: Our data indicate that the interpretation of plasma folate concentrations to assess folate nutritional status is complicated by BMI, although the impact of BMI on plasma folate was relatively small. It is important to take this association into account for the selection of subjects for future large-scale studies. The mechanism of this inverse association between BMI and plasma folate concentrations should be investigated. | |||||
書誌情報 |
European journal of nutrition 巻 50, 号 7, p. 581-585, 発行日 2011-10 |
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出版者 | ||||||
出版者 | Springer-Verlag | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14366207 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14366215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11323696 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21221977 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00394-010-0165-0 | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2011 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European journal of nutrition, 50(7), pp.581-585; 2011 |