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Production of IFN- by CD4+ T cells in response to malaria antigens is IL-2 dependent
http://hdl.handle.net/10069/27002
http://hdl.handle.net/10069/27002a403d50b-480b-4d86-943b-76aede587452
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IntImm22_941.pdf (545.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-04 | |||||
| タイトル | ||||||
| タイトル | Production of IFN- by CD4+ T cells in response to malaria antigens is IL-2 dependent | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mouse | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Parasite | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kimura, Daisuke
× Kimura, Daisuke× Miyakoda, Mana× Honma, Kiri× Shibata, Yoshisada× Yuda, Masao× Chinzei, Yasuo× Yui, Katsuyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4+ T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). CD4+ T cells from PbA-infected mice produced IFN-γ, IL-4 and IL-10 in response to TCR stimulation at levels higher than those from uninfected mice. This altered cytokine response was dependent on parasitemia. To examine the specificity of the response, mice were adoptively transferred with CD4+ T cells from OT-II TCR transgenic mice and were infected with PbA expressing OVA. Unexpectedly, CD4+ T cells from the OT-II-transferred wild-type PbA-infected mice showed high levels of IFN-γ production after stimulation with OVA and the cells producing IFN-γ were not OT-II but were host CD4+ T cells. Further investigation revealed that host CD4+ T cells produced IFN-γ in response to IL-2 produced by activated OT-II cells. This IFN-γ response was completely inhibited by anti-CD25 mAbs, and this effect was not due to the block of the survival signals provided by IL-2. Furthermore, IFN-γ production by CD4+ T cells in response to PbA antigens was dependent on IL-2. These findings suggest the importance of IL-2 levels during infection with malaria parasites and indicate that CD4+ T cells can produce IFN-γ without TCR engagement via a bystander mechanism in response to IL-2 produced by other activated CD4+ T cells. | |||||
| 書誌情報 |
International Immunology 巻 22, 号 12, p. 941-952, 発行日 2010-12-13 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09538178 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14602377 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10730708 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/intimm/dxq448 | |||||
| 権利 | ||||||
| 権利情報 | © The Japanese Society for Immunology. 2010. All rights reserved. | |||||
| 権利 | ||||||
| 権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version International Immunology, 22(12), pp.941-952; 2010 is available online at: http://dx.doi.org/10.1093/intimm/dxq448. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Immunology, 22(12), pp.941-952; 2010 | |||||
