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Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters.
http://hdl.handle.net/10069/22959
http://hdl.handle.net/10069/22959e83202db-16d1-4100-8a89-764bdb95b3fd
名前 / ファイル | ライセンス | アクション |
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Car29_830.pdf (234.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-24 | |||||
タイトル | ||||||
タイトル | Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intraductal papillary mucinous neoplasm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intraductal papillary mucinous neoplasm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclooxygenase-2 inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemoprevention | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hamster | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Adachi, Tomohiko
× Adachi, Tomohiko× Tajima, Yoshitsugu× Kuroki, Tamotsu× Mishima, Takehiro× Kitasato, Amane× Tsuneoka, Noritsugu× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was designed to determine whether etodolac, a selective cyclooxygenase-2 inhibitor, prevents chemically induced intraductal papillary carcinoma (IPC) in the main pancreatic duct of hamsters. Hamsters were subjected to cholecystoduodenostomy with dissection of the distal end of the common duct. Four weeks after surgery, the surviving hamsters received subcutaneous injections of N-nitrosobis(2-oxopropyl)amine four times at a dose of 10 mg/kg body wt, every 2 weeks. The animals were divided into three groups according to the simultaneous oral intake of a standard pelleted diet containing etodolac at 0% (group CE, n = 30), 0.01% (group ET, n = 21) and 0.04% (group ET4, n = 25), respectively. Hamsters were killed for pathological examination at 36 weeks after the operation. The incidence of induced pancreatic carcinoma was 93, 81 and 72% in groups CE, ET and ET4, respectively. The pancreatic carcinomas were histologically classified into four types, i.e. tubular, papillary, cyst adenocarcinoma and IPC. The incidence of IPC and the number of IPCs per animal were significantly lower in groups ET4 (36% and 0.48) and ET (48% and 0.62) when compared with group CE (67% and 1.30). The proliferating cell nuclear antigen labeling indices in the non-cancerous epithelial cells of the main pancreatic duct were 2.8 and 6.8% in groups ET4 and ET, respectively, and were significantly lower than that in group CE (10.8%). In conclusion, etodolac inhibited N-nitrosobis(2-oxopropyl)amine-induced IPC in hamsters. Suppression of epithelial cell proliferation of the main pancreatic duct was considered as a possible mechanism of cancer prevention in this hamster model. | |||||
書誌情報 |
Carcinogenesis 巻 29, 号 4, p. 830-833, 発行日 2008-04 |
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出版者 | ||||||
出版者 | Oxford University Press. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01433334 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1460-2180 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00141799 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18296437 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/carcin/bgn047 | |||||
権利 | ||||||
権利情報 | © The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org | |||||
権利 | ||||||
権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Carcinogenesis following peer review. The definitive publisher-authenticated version Carcinogenesis, 29(4), pp.830-833; 2008 is available online at: http://carcin.oxfordjournals.org/cgi/content/abstract/29/4/830. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Carcinogenesis, 29(4), pp.830-833; 2008 |