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Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients.
http://hdl.handle.net/10069/23203
http://hdl.handle.net/10069/232035f0694fe-7078-4b22-8ca0-8793d90cbc34
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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公開日 | 2010-06-16 | |||||||||||||||||||||||||
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タイトル | Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients. | |||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||
主題 | 14-3-3 Protein | |||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||
主題 | Creutzfeldt-Jakob disease (CJD) | |||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||
主題 | CSF | |||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||
主題 | H-FABP | |||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||
主題 | Prion disease | |||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||||
著者 |
Matsui, Yuki
× Matsui, Yuki
× Satoh, Katsuya
× Mutsukura, Kazuo
× Watanabe, Takuya
× Nishida, Noriyuki
× Matsuda, Hideo
× Sugino, Masaichi
× Shirabe, Susumu
× Eguchi, Katsumi
× Kataoka, Yasufumi
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抄録 | ||||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||||
内容記述 | Creutzfeldt-Jakob disease (CJD) is a transmissible, fatal, neurodegenerative disease in humans. Recently, various drugs have been reported to be useful in the treatment of CJD; however, for such treatments to be useful it is essential to rapidly and accurately diagnose CJD. 124 CJD patients and 87 with other diseases causing rapid progressive dementia were examined. Cerebral spinal fluid (CSF) from CJD patients was analyzed by 2D-PAGE and the protein expression pattern was compared with that from healthy subjects. One of three CJD-specific spots was found to be fatty acid binding protein (FABP), and heart-type FABP (H-FABP) was analyzed as a new biochemical marker for CJD. H-FABP ELISA results were compared between CJD patients and patients with other diseases (n = 211). Visual readout accuracy of the Rapicheck((R)) H-FABP test panel for CSF was analyzed using an independent measure of CSF H-FABP concentration. The distribution of H-FABP in the brains of CJD patients was examined by immunohistochemistry. ELISA sensitivity and specificity were 90.3% and 92.9%, respectively, and Rapicheck((R)) H-FABP sensitivity and specificity were 87.9% and 96.0%, respectively. ELISA and Rapicheck((R)) H-FABP assays provided comparable results for 14-3-3 protein and total tau protein. Elevated H-FABP levels were associated with an accumulation of abnormal prion protein, astrocytic gliosis, and neuronal loss in the cerebral cortices of CJD patients. In conclusion, Rapicheck((R)) H-FABP of CSF specimens enabled quick and frequent diagnosis of CJD. H-FABP represents a new biomarker for CJD distinct from 14-3-3 protein and total tau protein. | |||||||||||||||||||||||||
内容記述 | ||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||
内容記述 | The original publication is available at www.springerlink.com | |||||||||||||||||||||||||
書誌情報 |
Cellular and molecular neurobiology 巻 30, 号 7, p. 991-999, 発行日 2010-10 |
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出版者 | ||||||||||||||||||||||||||
出版者 | Springer Netherlands | |||||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
収録物識別子 | 02724340 | |||||||||||||||||||||||||
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
収録物識別子 | 15736830 | |||||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||||
収録物識別子 | AA10622352 | |||||||||||||||||||||||||
PubMed番号 | ||||||||||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||||||||
関連識別子 | 20499272 | |||||||||||||||||||||||||
DOI | ||||||||||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||||
関連識別子 | 10.1007/s10571-010-9529-5 | |||||||||||||||||||||||||
権利 | ||||||||||||||||||||||||||
権利情報 | © Springer Science+Business Media, LLC 2010 | |||||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||||
出版タイプ | AM | |||||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||||
引用 | ||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||
内容記述 | Cellular and molecular neurobiology, 30(7), pp.991-999; 2010 |