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Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion
http://hdl.handle.net/10069/38802
http://hdl.handle.net/10069/38802db5bed0a-598a-436c-9f2c-fb01e8b788a9
名前 / ファイル | ライセンス | アクション |
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Fnimmu9_2942.pdf (3.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-30 | |||||
タイトル | ||||||
タイトル | Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clonal expansion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metformin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γδ T cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyakoda, Mana
× Miyakoda, Mana× Bayarsaikhan, Ganchimeg× Kimura, Daisuke× Akbari, Masoud× Udono, Heiichiro× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adaptive immune responses are critical for protection against infection with Plasmodium parasites. The metabolic state dramatically changes in T cells during activation and the memory phase. Recent findings suggest that metformin, a medication for treating type-II diabetes, enhances T-cell immune responses by modulating lymphocyte metabolism. In this study, we investigated whether metformin could enhance anti-malaria immunity. Mice were infected with Plasmodium yoelii and administered metformin. Levels of parasitemia were reduced in treated mice compared with those in untreated mice, starting at ~2 weeks post-infection. The number of γδ T cells dramatically increased in the spleens of treated mice compared with that in untreated mice during the later phase of infection, while that of αβ T cells did not. The proportions of Vγ1+ and Vγ2+ γδ T cells increased, suggesting that activated cells were selectively expanded. However, these γδ T cells expressed inhibitory receptors and had severe defects in cytokine production, suggesting that they were in a state of exhaustion. Metformin was unable to rescue the cells from exhaustion at this stage.Depletion of γδ T cells with antibody treatment did not affect the reduction of parasitemia in metformin-treated mice, suggesting that the effect of metformin on the reduction of parasitemia was independent of γδ T cells. |
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書誌情報 |
Frontiers in Immunology 巻 9, p. 2942, 発行日 2018-12-13 |
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出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16643224 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fimmu.2018.02942 | |||||
権利 | ||||||
権利情報 | c2018 Miyakoda, Bayarsaikhan, Kimura, Akbari, Udono and Yui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in immunology, 9, 2942; 2018 |