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Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity.
http://hdl.handle.net/10069/23326
http://hdl.handle.net/10069/23326424fad15-a8b3-4ae0-9d54-944d0c656ede
名前 / ファイル | ライセンス | アクション |
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NeuAgi33_535.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-07-22 | |||||
タイトル | ||||||
タイトル | Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebellum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Long term potentiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxidative agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parallel fiber | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Posttetanic potentiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Purkinje cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | S-nitrosylation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kakizawa, Sho
× Kakizawa, Sho× Shibazaki, Masahiko× Mori, Nozomu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oxidative stress is a primary factor inducing brain dysfunction in aged animals. However, how oxidation affects brain function is not fully understood. Here we show that oxidation inhibits signaling pathways essential for synaptic plasticities in the cerebellum. We first revealed that nitric oxide (NO)-dependent plasticities at the parallel fiber-Purkinje cell synapse (PF synapse) were impaired in the cerebellar slices from aged mice, suggesting a possible inhibitory action of protein oxidation by endogenous reactive oxygen species. PF-synaptic plasticities were also blocked in the cerebellar slices from young mice preincubated with oxidizing agents or thiol blocker. Because the treatment of the slices with the oxidizing agent did not affect basic electrophysiological properties of excitatory postsynaptic current of PF (PF-EPSC) and did not occlude the synaptic plasticities, oxidation was revealed to specifically inhibit signaling pathways essential for PF-synaptic plasticities. Finally, biochemical analysis confirmed the idea that inhibitory action of protein oxidation on the PF-synaptic plasticities was mediated by impairment of nitric oxide-induced protein S-nitrosylation. Therefore, oxidation was revealed to inhibit the S-nitrosylation-dependent signaling pathway essential for synaptic plasticity in a "competitive" manner. | |||||
書誌情報 |
Neurobiology of aging 巻 33, 号 3, p. 535-545, 発行日 2012-03 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01974580 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15581497 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10618297 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20580131 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neurobiolaging.2010.04.016 | |||||
権利 | ||||||
権利情報 | Copyright © 2010 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neurobiology of Aging, 33(3), pp.535-545; 2012 |