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Antinociceptive Effect of Dihydroetorphine and Its Tolerance/Dependence Liability in Mice.
http://hdl.handle.net/10069/38834
http://hdl.handle.net/10069/38834739461f7-9a92-4aae-85f9-c96a936e5909
名前 / ファイル | ライセンス | アクション |
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BPB16_774.pdf (617.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Antinociceptive Effect of Dihydroetorphine and Its Tolerance/Dependence Liability in Mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dihydroetorphine (DHE) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | physical dependence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinociception | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tolerance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | locomotor activity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TOKUYAMA, Shogo
× TOKUYAMA, Shogo× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The profile of actions of dihydroetorphine (DHE) concerning antinociception, tolerance and dependence was compared with those of morphine in mice. DHE at 1, 5, 10 or 20μg/kg produced an antinociceptive effect in a dose dependent manner and 10μg/kg was nearly equipotent to that of 10mg/kg of morphine. The antinociceptive effect of both drugs was completely suppressed by 1mg/kg of naloxone, while neither 10mg/kg of naltrindole nor 1mg/kg of nor-binaltorphimine had any suppressive effect. Mice tolerant to morphine antinociception were tolerant to DHE and vice versa. The naloxone-sensitive, locomotor accelerating activity was progressively enhanced by daily administration of DHE and morphine and a cross reverse tolerance developed between these compounds, suggesting that common mechanisms, especially mediating opioid receptors, underlay the activity enhancement. The development of physical dependence as evidenced by naloxone precipitated withdrawal signs, however, was not observed with daily treatment with DHE, 10, 20 and 100μg/kg for 6d. Thus, we demonstrated that DHE produces the antinociceptive effect mediated through μ opioid receptors without causing development of a physical dependence, suggesting that it is safe to use in the clinical therapy of patients suffering severe pain such as that accompanying cancer. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 16, 号 8, p. 774-777, 発行日 1993-08-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.16.774 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 16(8), pp.774-777; 1993 |