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Modulation of Morphine Action by Lauric Acid.
http://hdl.handle.net/10069/38835
http://hdl.handle.net/10069/38835980540cd-8172-4830-a047-86162ad13541
名前 / ファイル | ライセンス | アクション |
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BPB16_806.pdf (432.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Modulation of Morphine Action by Lauric Acid. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lauric acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinociceptive effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tolerance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MIWA, Takaichi
× MIWA, Takaichi× NAKAO, Kaoru× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Intraperitoneal administration of lauric acid (C12) at the high doses, 100-1000μmol/kg, showed weak but dose-dependent antinociceptive effect in mice. Pretreatment of the animals with 0.1μmol/kg of i.p. C12 tended to suppress the antinociceptive effect of 7mg/kg of s.c. morphine and daily combination of this dose of C12 with 10mg/kg of s.c. morphine blocked the development of antinociceptive tolerance to morphine. However, increasing or decreasing of the dose of C12 resulted in the loss of its modulatory effect on morphine. The strict dose-dependency of C12 in its action on morphine suggests that there is a regulatory role for C12, a medium length straight chain fatty acid, in the endogenous pain inhibitory system. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 16, 号 8, p. 806-807, 発行日 1993-08-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.16.806 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 16(8), pp.806-807; 1993 |