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The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
http://hdl.handle.net/10069/38849
http://hdl.handle.net/10069/38849c55b534b-ac5b-419f-9213-05baac4c8287
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JPD13_448.pdf (666.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-02-21 | |||||
| タイトル | ||||||
| タイトル | The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | receptor binding assay | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KANETO, Hiroshi
× KANETO, Hiroshi× TAKAHASHI, Masakatsu× WATANABE, Joe |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Differences of affinity ot and selectivity for trimebutine between peripheral and central opioid receptors have been investigated. Trimebutine inhibited electrically induced contraction of guinea-pig ileum (GPI) and mouse vas deferens (MVD) but not of rabbit vas deferens, and the inhibition was antagonized by naloxone and, to lesser extent, by nor-binaltorphimine (nor-BNI). The pA2 values for morphine and trimebutine with naloxone were higher than the values for these compounds with nor-BNI in both GPI and MVD preparations. GPI preparations incubated with a high concentration of morphine or trimebutine developed tolerance ; however, there was no cross-tolerance between them, suggesting difference in the underlying mechanisms. In mouse and guinea-pig brain homogenate trimebutine was about 1/13 as potent as morphine to displace the [3H]naloxone binding, while it has no appreciable affinity for κ-opioid receptors in [3H]U-69593, a selective κ-receptor agonist. These results suggest that trimebutine, showing its low affinity to opioid receptors, possesses μ-receptor selective properties rather than those of κ-opioid receptor in the peripheral tissues and in the central brain homogenate. | |||||
| 書誌情報 |
Journal of Pharmacobio-Dynamics 巻 13, 号 7, p. 448-453, 発行日 1990 |
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| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
| 出版者別言語 | ||||||
| 値 | Pharmaceutical Society of Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0386846X | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18811353 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00704585 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/bpb1978.13.448 | |||||
| 権利 | ||||||
| 権利情報 | c The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Pharmacobio-Dynamics, 13(7), pp.448-453; 1990 | |||||
