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Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation
http://hdl.handle.net/10069/38868
http://hdl.handle.net/10069/3886874851f9c-159c-4bfd-a1da-c44fafbc4da6
名前 / ファイル | ライセンス | アクション |
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BMT_Itonaga20190204.pdf (702.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-04 | |||||
タイトル | ||||||
タイトル | Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelodysplastic syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allogeneic hematopoietic stem cell transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monosomy 7 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | partial deletion of 7q | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | der(1;7)(q10;p10) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Itonaga, Hidehiro
× Itonaga, Hidehiro× Ishiyama, Ken× Aoki, Kazunari× Aoki, Jun× Ishikawa, Takayuki× Ohashi, Kazuteru× Fukuda, Takayuki× Ozawa, Yukiyasu× Ota, Shuichi× Uchida, Naoyuki× Eto, Tetsuya× Iwato, Koji× Ohno, Yuju× Takanashi, Minoko× Ichinohe, Tatsuo× Atsuta, Yoshiko× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We conducted a nationwide retrospective study to evaluate the prognostic influence of +1, der(1;7)(q10;p10) [hereafter der(1;7)] and ?7/del(7q) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for de novo myelodysplastic syndromes (MDS). In this database, 69 MDS patients with der(1;7), 75 with ?7/del(7q), and 511 with normal karyotype (NK) underwent allo-HSCT at advanced disease status. The 3-year overall survival (OS) and cumulative incidence of relapse (CIR) were 50.4 and 19.4% for those with der(1;7), 36.2 and 38.4% for ?7/del(7q),and 51.1 and 20.7% for NK, respectively. In the multivariate analysis, the presence of ?7/del(7q) correlated with a significantly shorter OS (HR [95% CI], 1.38 [1.00?1.89]; P = 0.048) and higher CIR (HR, 2.11 [1.36?3.28]; P = 0.001) than those with NK. There were 23 patients with der(1;7), 29 with ?7/del(7q), and 347 with NK who underwent allo-HSCT at early disease status.The 3-year OS and CIR were as follows: 47.3 and 9.5% for the der(1;7) group, 70.5 and 13.8% for ?7/del(7q), and 70.9 and 5.6% for NK,respectively. No significant differences were observed in OS and CIR among three groups. The impact of the loss of chromosome 7q on OS and CIR may differ based on its type and disease status after allo-HSCT for MDS. |
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書誌情報 |
Bone Marrow Transplantation 巻 54, 号 9, p. 1471-1481, 発行日 2019-02-04 |
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出版者 | ||||||
出版者 | Springer Nature Limited. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02683369 | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14765365 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41409-019-0469-5 | |||||
権利 | ||||||
権利情報 | c 2019, Springer Nature Limited. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone Marrow Transplantation, 54(9), pp.1471-1481; 2019 |