| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-05-22 |
| タイトル |
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|
タイトル |
Potential of Magnetic Resonance Plaque Imaging Using Superparamagnetic Particles of Iron Oxide for the Detection of Carotid Plaque |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
carotid plaque |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
functional imaging |
| キーワード |
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主題Scheme |
Other |
|
主題 |
high-resolution magnetic resonance imaging |
| キーワード |
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主題Scheme |
Other |
|
主題 |
macrophage |
| キーワード |
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主題Scheme |
Other |
|
主題 |
superparamagnetic particles of iron oxide |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kawahara, Ichiro
Nakamoto, Morito
Kitagawa, Naoki
Tsutsumi, Keisuke
Nagata, Izumi
Morikawa, Minoru
Hayashi, Tomayoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Macrophages and by-products are important in plaque destabilization in atherosclerosis. Ultra-small superparamagnetic particles of iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging may be suitable for the detection of macrophages in atherosclerotic plaques. The present study investigated the potential of MR plaque imaging using SPIO in 10 patients scheduled for carotid endarterectomy before and 24-43 hours after administration of SPIO (fercarbotran, 0.016 ml/kg). Three-dimensional gradient recalled acquisition in the steady state (3D-GRASS) was used for detecting macrophages within plaques. Signal loss on the post-contrast 3D-GRASS images was found in 5 of 10 cases, and accumulation of SPIO particles in the vessel wall was confirmed in 4 of these 5 cases. Intracytoplasmic localization of SPIO particles within recruited macrophages was verified by double staining analysis. A correlation between MR plaque imaging using SPIO and localization of macrophages was demonstrated in 6 of 10 patients. This study indicates that MR plaque imaging using SPIO is a potential functional imaging tool to detect infiltration of macrophages in human atherosclerotic carotid plaque. |
| 書誌情報 |
Neurologia medico-chirurgica
巻 48,
号 4,
p. 157-162,
発行日 2008-04
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| 出版者 |
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出版者 |
The Japan Neurosurgical Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
04708105 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00358613 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.2176/nmc.48.157 |
| 権利 |
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|
権利情報 |
Copyright (c) 2008 by The Japan Neurosurgical Society |
| 権利 |
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権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Neurologia medico-chirurgica, 48(4), pp.157-162; 2008 |
110006656285.pdf (843.1 kB)
