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Immunological aspects of adult T-cell leukemia/lymphoma (ATLL), a possible neoplasm of regulatory T-cells
http://hdl.handle.net/10069/22532
http://hdl.handle.net/10069/225322626850a-5ee1-4b00-a3d3-1d6577ab79f2
名前 / ファイル | ライセンス | アクション |
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CIR_4_4_242.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-03 | |||||
タイトル | ||||||
タイトル | Immunological aspects of adult T-cell leukemia/lymphoma (ATLL), a possible neoplasm of regulatory T-cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T-cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | causative agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunological aspects | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glucocorticoid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T-lymphocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oncogenic retrovirus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Yasuaki
× Yamada, Yasuaki× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult T-cell leukemia/lymphoma (ATLL) is a distinct disease caused by the first discovered human oncogenic retrovirus, human T-cell leukemia virus type-1 (HTLV-1). The peculiarity of this disease is not only in its causative agent HTLV-1 but also in the character of leukemia cells. ATLL cells express the mature helper/inducer T-cell antigens, CD2, CD3, CD4 and CD5 but usually lacking CD8. Despite CD4 expression, it has long been known that ATLL cells exhibit strong immunosuppressive activity in vitro. Notably, ATLL patients are in severely immunosuppressed conditions and this causes higher incidences of opportunistic infections than other types of leukemia and lymphoma. Since ATLL cells constitutively express CD25, this prompted investigators to study ATLL cells from the viewpoint of regulatory T cells (Treg cells). ATLL cells satisfy all the criteria of Treg cells, as they express Foxp3, the master gene of Treg lineage, the glucocorticoid-induced TNF receptor (GITR), and the cytotoxic T-lymphocyte associated molecul-4 (CTLA-4). Moreover, other profiles including chemokine receptor expression also support that ATLL is a neoplasm of Treg cell origin. Here we review the immunological aspects of ATLL cells and discuss this cell origin. | |||||
書誌情報 |
Current Immunology Reviews 巻 4, 号 4, p. 242-250, 発行日 2008-11 |
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出版者 | ||||||
出版者 | Bentham Science Publishers | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15733955 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12061799 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2174/157339508786447896 | |||||
権利 | ||||||
権利情報 | (c) 2008 Bentham Science Publishers Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Current Immunology Reviews, 4 (4) pp. 242-250;2008 |