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CEL-I, an N-acetylgalactosamine (GalNAc)-specific C-type lectin, induces nitric oxide production in RAW264.7 mouse macrophage cell line.
http://hdl.handle.net/10069/23065
http://hdl.handle.net/10069/23065e2ce373e-4599-4fde-966e-8cb6af7498b7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JB146_209.pdf (155.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-12 | |||||
| タイトル | ||||||
| タイトル | CEL-I, an N-acetylgalactosamine (GalNAc)-specific C-type lectin, induces nitric oxide production in RAW264.7 mouse macrophage cell line. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CEL-I | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | C-type lectin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cucumaria echinata | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | inducible nitric oxide synthase (iNOS) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nitric oxide (NO) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamanishi, Tomohiro
× Yamanishi, Tomohiro× Hatakeyama, Tomomitsu× Yamaguchi, Kenichi× Oda, Tatsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We found that CEL-I, a GalNAc-specific C-type lectin isolated from the marine invertebrate Holothuroidea (Cucumaria echinata), induces inducible nitric oxide synthase (iNOS) expression and NO production in RAW264.7 cells. The NO production was inhibited by an iNOS inhibitor, L-NAME, but was not by a lipopolysaccharide (LPS) inhibitor, polymyxin B. In the presence of 0.1-M GalNAc, increased NO production by CEL-I-treated RAW264.7 cells was observed rather than the inhibition. Bovine serum albumin (BSA) significantly inhibited the CEL-I-induced NO production as well as the binding of FITC-labelled CEL-I on RAW264.7 cells. Three MAP kinase inhibitors (specific to extra-cellular regulated kinase, c-jun NH(2)-terminal kinase and p38 MAP kinase) inhibited CEL-I-induced NO production with different extents. Heat-treatment of CEL-I resulted in a decreased activity of CEL-I depending on the temperature. These results suggest that CEL-I induces NO production in RAW264.7 cells through the protein-cell interaction rather than the binding to the specific carbohydrate chains on the cell surface. | |||||
| 書誌情報 |
Journal of biochemistry 巻 146, 号 2, p. 209-217, 発行日 2009-08 |
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| 出版者 | ||||||
| 出版者 | Japanese Biochemical Society | |||||
| 出版者別言語 | ||||||
| 値 | 日本生化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021924X | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17562651 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00694073 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19351706 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jb/mvp057 | |||||
| 権利 | ||||||
| 権利情報 | c The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved | |||||
| 権利 | ||||||
| 権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in "Journal of Biochemistry" following peer review. The definitive publisher-authenticated version "Journal of Biochemistry 2009 146(2):209-217" is available online at: http://jb.oxfordjournals.org/cgi/content/abstract/146/2/209 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関係URI | ||||||
| 関連名称 | http://jb.oxfordjournals.org/ | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of biochemistry, 146(2), pp.209-217; 2009 | |||||
