| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-11 |
| タイトル |
|
|
タイトル |
Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Adult T-cell leukemia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hematological malignancy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Interstitial pneumonia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Krebs von den Lungen-6 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Surfactant protein-D |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Osaka, Akemi
Yanagihara, Katsunori
Yamada, Yasuaki
Hasegawa, Hiroo
Inokuchi, Naoko
Hayashi, Tomayoshi
Komoda, Minori
Nakamura, Shigeki
Aoyama, Muneo
Sawada, Takashi
Kamihira, Shimeru
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Patients with hematological malignancies frequently suffer from lung diseases as a complication. However, it is difficult to discriminate leukemic invasion into the lung from infectious pulmonary complications. The serum level of Krebs von den Lungen-6 (KL-6), which is a mucin-like glycoprotein, is increased in more than 70% of patients with interstitial pneumonia. Surfactant protein-D (SP-D) is produced mainly in the lung by alveolar type II and bronchiolar epithelial cells and is a useful serum marker for interstitial pneumonia. We therefore measured the levels of KL-6 and SP-D in sera from 128 patients (76 males and 52 females, mean age: 59 years) with hematological malignancies, including adult T-cell leukemia (ATL). Overall, the increase in KL-6 or SP-D, above each cut-off value (500 U/ml for KL-6 and 110 ng/ml for SP-D), was detected in 11 patients (8.6%) or 10 patients (7.8%), respectively. In contrast, among 67 ATL patients, 15 patients had high serum levels of KL-6 and/or SP-D; both were elevatedin 2 patients, only KL-6 was elevated in 6 patients and only SP-D was elevated in 7 patients. Thus, serum KL-6 and SP-D appear to be elevated in a mutually exclusive manner in ATL. Indeed, high serum levels of KL-6 were closely related to the stage of ATL, while the serum SP-D was elevated in ATL patients with pulmonary infection. In conclusion, the combined measurement of KL-6 and SP-D in ATL may become a useful means to discriminate leukemic pulmonary lesions from infectious pulmonary complications. |
| 書誌情報 |
The Tohoku Journal of Experimental Medicine
巻 218,
号 2,
p. 99-105,
発行日 2009-06
|
| 出版者 |
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|
出版者 |
Tohoku University |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00408727 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-3329 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00863920 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1620/tjem.218.99 |
| 権利 |
|
|
権利情報 |
c 2009 Tohoku University Medical Press. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The Tohoku Journal of Experimental Medicine, 218(2), pp.99-105 |
TJEM218_99.pdf (1.0 MB)
