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Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma.
http://hdl.handle.net/10069/23196
http://hdl.handle.net/10069/23196a9a56508-1c4c-484d-aa93-ffa017415d0c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ASO16_2123.pdf (673.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-06-11 | |||||
| タイトル | ||||||
| タイトル | Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intrahepatic cholangiocarcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatic resection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microvessel count | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD34 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Shibata, Kenichiro× Nakayama, Toshiyuki× Tobinaga, Syuichi× Araki, Masato× Kunizaki, Masaki× Takeshita, Hiroaki× Hidaka, Shigekazu× Sawai, Terumitsu× Nagayasu, Takeshi× Tagawa, Tsutomu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and prognosis in intrahepatic cholangiocarcinoma (ICC) patients who underwent hepatectomy based on our preliminary study. METHODS: Relationships between MVC and clinicopathological factors were examined in 37 ICC patients. CD34 expression was analyzed using immunohistochemical methods. RESULTS: Median MVC for ICC patients was 140/mm(2), which was applied as a cutoff value. Lower MVC was significantly associated with larger tumor size, periductal infiltrating type, and advanced Japanese tumor-node-metastasis stage (p < 0.05). Univariate survival analysis identified higher carcinoembryonic antigen level, periductal infiltrating type, poor histological differentiation, and lower MVC as significantly associated with lower 5-year survival rates. The 5-year survival rate in the higher-MVC group was significantly greater than that in the lower-MVC group (44% vs. 7%, p = 0.048). According to Cox multivariate survival analysis, only periductal infiltrating type on macroscopic examination was identified as a significant independent risk factor for poor survival after hepatectomy (risk ratio 4.8; p = 0.006), not MVC (1.1; p = 0.82). CONCLUSION: Tumor MVC might offer a useful prognostic marker of ICC patient survival after hepatectomy and further investigation in a larger series is warranted. | |||||
| 書誌情報 |
Annals of surgical oncology 巻 16, 号 8, p. 2123-2129, 発行日 2009-08 |
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| 出版者 | ||||||
| 出版者 | Springer New York | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10689265 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15344681 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11016573 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19434454 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1245/s10434-009-0494-5 | |||||
| 権利 | ||||||
| 権利情報 | c 2009 Society of Surgical Oncology. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annals of Surgical Oncology, 16(8), pp.2123-2129; 2009 | |||||
