| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-10-02 |
| タイトル |
|
|
タイトル |
Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway. |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Olprinone |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
isoflurane |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
diabetes |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
mitochondrial ATP-sensitive potassium channels |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
phosphatidylinositol 3-kinase-Akt |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Matsumoto, Shuhei
Cho, Sungsam
Tosaka, Shinya
Ureshino, Hiroyuki
Maekawa, Takuji
Hara, Tetsuya
Sumikawa, Koji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
PURPOSE: The authors examined whether olprinone, a phosphodiesterase type 3 inhibitor, or isoflurane, a volatile anesthetic, could protect the heart against myocardial infarction in type 2 diabetic rats and whether the underlying mechanisms involve protein kinase C (PKC), mitochondrial ATP-sensitive potassium (m-K(ATP)) channels, or the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. METHODS: All rats underwent 30 min of coronary artery occlusion followed by 2 h of reperfusion. Wistar rats received isoflurane or olprinone before ischemia with or without the PKC inhibitor chelerythrine (CHE), the m-K(ATP) channel blocker 5-hydroxydecanoic acid (5HD), or the PI3K-Akt inhibitor LY294002 (LY). Goto-Kakizaki (GK) rats were randomly assigned to receive isoflurane or olprinone. In another group, GK rats received LY before the olprinone. RESULTS: In the Wistar rats, both isoflurane (38 +/- 11%) and olprinone (40 +/- 11%) reduced infarct size as compared to the control group (59 +/- 8%). In the GK rats, olprinone (41 +/- 9%) but not isoflurane (53 +/- 11%) reduced infarct size as compared to the GK control group (58 +/- 14%). The beneficial effects of olprinone were blocked by LY (58 +/- 14%). In the Wistar rats, CHE, 5HD, and LY prevented isoflurane-induced reductions of infarct size. On the other hand, LY but not CHE or 5HD prevented olprinone-induced reductions of infarct size. CONCLUSIONS: Olprinone but not isoflurane protects the heart against myocardial infarction in type 2 diabetic rats. The olprinone-induced cardioprotective effect is mediated by the PI3K-Akt pathway but not PKC or m-K(ATP) channels. |
| 書誌情報 |
Cardiovascular Drugs and Therapy
巻 23,
号 4,
p. 263-270,
発行日 2009-08
|
| 出版者 |
|
|
出版者 |
Springer |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09203206 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1573-7241 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10691796 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
19597978 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s10557-009-6184-5 |
| 権利 |
|
|
権利情報 |
c Springer Science+Business Media, LLC 2009 |
| 権利 |
|
|
権利情報 |
The original publication is available at www.springerlink.com |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Cardiovascular Drugs and Therapy, 23(4), pp.263-270; 2009 |
CDT23_4_263.pdf (483.5 kB)
