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Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
http://hdl.handle.net/10069/24038
http://hdl.handle.net/10069/24038b8de0dc4-9bba-424b-86b2-dd4cfe58cae8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HepRes39_856.pdf (187.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-10-01 | |||||
| タイトル | ||||||
| タイトル | Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chronic hepatitis C | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | First phase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hepatitis C virus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Interferon | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Living donor liver transplantation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ichikawa, Tatsuki
× Ichikawa, Tatsuki× Nakao, Kazuhiko× Miyaaki, Hisamitsu× Eguchi, Susumu× Takatsuki, Mitsuhisa× Fujimito, Masumi× Akiyama, Motohisa× Miuma, Satoshi× Ozawa, Eisuke× Shibata, Hidetaka× Takeshita, Shigeyuki× Kanematsu, Takashi× Eguchi, Katsumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: To identify the problems of pegylated interferon (PEG IFN) with ribavirin therapy against hepatitis C virus (HCV) reinfection in living donor liver transplantation (LDLT) patients. HCV kinetics during the PEG IFN with ribavirin therapy were analyzed in LDLT patients, as well as in chronic hepatitis C (CHC) patients. Methods: The study included 80 consecutive HCV infected patients undergoing PEG IFN with ribavirin therapy (64 CHC and 16 LDLT patients) who attended the Nagasaki University Hospital for an initial visit between January 2005 and December 2007. Results: The sustained viral response (VR) rate of the CHC group (80%) was superior to the LDLT group (22%). The viral disappearance rate of the CHC group was also superior to the LDLT group, regardless of the HCV serotype. The HCV core antigen (cAg) titer under treatment in the LDLT group was more than that of the CHC group from day 0 to week 12. The HCV cAg decrease rate of the LDLT group on the first day of treatment was less than that of the CHC group. Conclusion: The HCV infection of a transplanted liver is more refractory to treatment than a non-transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy. | |||||
| 書誌情報 |
Hepatology research : the official journal of the Japan Society of Hepatology 巻 39, 号 9, p. 856-864, 発行日 2009-09 |
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| 出版者 | ||||||
| 出版者 | Blackwell Publishing Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13866346 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11140867 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19624776 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1872-034X.2009.00524.x | |||||
| 権利 | ||||||
| 権利情報 | c 2009 The Japan Society of Hepatology | |||||
| 権利 | ||||||
| 権利情報 | This is the author's version of the work. It is posted here by permission of The Japan Society of Hepatology for personal use, not for redistribution. The definitive version was published in Hepatology Research, Volume 39, Issue 9, Pages 856-864. http://dx.doi.org/10.1111/j.1872-034X.2009.00524.x | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hepatology research, 39(9), pp.856-864; 2009 | |||||
