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Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation.
http://hdl.handle.net/10069/23179
http://hdl.handle.net/10069/23179089bcbc0-5697-4d91-b310-9d82a7acbc20
名前 / ファイル | ライセンス | アクション |
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JID129_2661.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-06-01 | |||||
タイトル | ||||||
タイトル | Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell adhesion molecules | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | contact hypersensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | elicitation phase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunosuppression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-10 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Komura, Kazuhiro
× Komura, Kazuhiro× Iwata, Yohei× Ogawa, Fumihide× Yoshizaki, Ayumi× Yamaoka, Toshifumi× Akiyama, Yuichiro× Hara, Toshihide× Hasegawa, Minoru× Fujimoto, Manabu× Sato, Shinichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Painting subsensitizing doses of contact sensitizers on skin (low-dose tolerization) induces antigen (Ag)-specific tolerance, known as low zone tolerance (LZT), which has been experimentally demonstrated by the inhibition of contact hypersensitivity (CHS). Although LZT resulted from the inhibition of the sensitization phase, the effects on the effector/elicitation phase remain unknown. L-selectin and ICAM-1 regulate leukocyte influx into inflamed tissues during the elicitation phase of CHS. LZT was investigated in mice lacking either L-selectin or ICAM-1 to evaluate the roles these leukocyte receptors play in LZT during the elicitation phase. Low-dose tolerization effectively suppressed CHS in wild-type and L-selectin-deficient mice, but not in ICAM-1-deficient mice. Low-dose-tolerized ICAM-1-deficient splenocytes effectively suppressed the elicitation phase in naive wild-type recipients. Sensitized ICAM-1-deficient splenocytes showed normal proliferative responses to the sensitizing Ag and generated normal CHS in wild-type recipients. Thus, ICAM-1 deficiency did not affect sensitization. LZT was associated with a lack of ICAM-1 upregulation after elicitation, suggesting a potentially mechanistic role for ICAM-1. The blockade of IL-10, a possible mediator of LZT, produced by hapten-specific suppressor cells, abrogated LZT and restored ICAM-1 upregulation. These results indicate that low-dose tolerization controls CHS by abrogating ICAM-1 upregulation during the elicitation phase. | |||||
書誌情報 |
The Journal of investigative dermatology 巻 129, 号 11, p. 2661-2667, 発行日 2009-11 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022202X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15231747 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00700733 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19536145 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/jid.2009.145 | |||||
権利 | ||||||
権利情報 | c 2009 The Society for Investigative Dermatology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of investigative dermatology, 129(11), pp.2661-2667; 2009 |