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Syrian golden hamsters underwent choledochojejunostomy and then received subcutaneous injections of the chemical carcinogen N-nitrosobis(2-oxopropyl)amine every 2 weeks at a dose of 10 mg/kg body wt, starting 4 weeks after surgery and continuing for 18 weeks. The hamsters were divided into two groups according to their oral intake of either a standard pelleted diet containing ONO-1714 at 100 p.p.m. for 18 weeks (ONO group, n = 15) or an ordinary diet alone (control group, n = 15). The animals were killed 22 weeks after surgery, and the development of biliary tumors was examined histologically. The presence and degree of cholangitis, cell kinetic status of the biliary epithelium and iNOS expression were evaluated. Intrahepatic biliary adenomas developed in all control animals, whereas they developed in only seven (47%) hamsters treated with ONO-1714 (P \u003c 0.05). 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Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters.
http://hdl.handle.net/10069/24406
http://hdl.handle.net/10069/244067389cf77-490d-42e3-9d23-d4d2f9960252
名前 / ファイル | ライセンス | アクション |
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Carcinogenesis30_1763.pdf (907.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-01 | |||||
タイトル | ||||||
タイトル | Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemoprevention | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biliary carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitric oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inducible nitric oxide synthase (iNOS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | iNOS inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholangitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bilioenterostomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hamster | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mishima, Takehiro
× Mishima, Takehiro× Tajima, Yoshitsugu× Kuroki, Tamotsu× Kosaka, Taiichiro× Adachi, Tomohiko× Kitasato, Amane× Tsuneoka, Noritsugu× Kitajima, Tomoo× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was designed to investigate whether an inducible nitric oxide synthase (iNOS)-specific inhibitor, ONO-1714 [(1S, 5S, 6R, 7R)-7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0] heptane], could prevent inflammation-associated biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters underwent choledochojejunostomy and then received subcutaneous injections of the chemical carcinogen N-nitrosobis(2-oxopropyl)amine every 2 weeks at a dose of 10 mg/kg body wt, starting 4 weeks after surgery and continuing for 18 weeks. The hamsters were divided into two groups according to their oral intake of either a standard pelleted diet containing ONO-1714 at 100 p.p.m. for 18 weeks (ONO group, n = 15) or an ordinary diet alone (control group, n = 15). The animals were killed 22 weeks after surgery, and the development of biliary tumors was examined histologically. The presence and degree of cholangitis, cell kinetic status of the biliary epithelium and iNOS expression were evaluated. Intrahepatic biliary adenomas developed in all control animals, whereas they developed in only seven (47%) hamsters treated with ONO-1714 (P < 0.05). Intrahepatic biliary carcinomas were present in 13 (87%) hamsters in the control group and in only 6 (40%) hamsters in the ONO groups (P < 0.05). Histological and immunohistochemical examinations demonstrated a significant decrease in the degree of cholangitis, biliary epithelial cell kinetics and the expression of iNOS in the biliary epithelium in the ONO group in comparison with the control (P < 0.05). These results indicate that ONO-1714 represses N-nitrosobis(2-oxopropyl)amine-induced biliary carcinogenesis in bilioenterostomized hamsters and inhibits iNOS expression in the biliary epithelium. ONO-1714 may therefore be a promising agent for the prevention of biliary carcinoma in various inflammation-associated biliary disorders. | |||||
書誌情報 |
Carcinogenesis 巻 30, 号 10, p. 1763-1767, 発行日 2009-10 |
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出版者 | ||||||
出版者 | Oxford University Press. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01433334 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14602180 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00141799 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19696162 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/carcin/bgp194 | |||||
権利 | ||||||
権利情報 | c The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/24789 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Carcinogenesis, 30(10), pp.1763-1767; 2009 |