WEKO3
アイテム
Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression.
http://hdl.handle.net/10069/22665
http://hdl.handle.net/10069/226650c655f76-216d-409d-bdcf-57fa6b058576
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Pathobiology75_257.pdf (489.5 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-28 | |||||
| タイトル | ||||||
| タイトル | Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Human papillomavirus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oral verrucous carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumorigenesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Fujita, Shuichi
× Fujita, Shuichi× Senba, Masachika× Kumatori, Atsushi× Hayashi, Tomayoshi× Ikeda, Tohru× Toriyama, Kan |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVE: Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, occurring mostly in oral mucosa. To clarify the role of human papillomavirus (HPV) in VC tumorigenesis, we investigated localization and genotypes of HPV and p53 expression in oral VC. METHODS: We studied paraffin-embedded specimens of 23 VCs and 10 control non-neoplastic lesions in oral mucosa. To investigate HPV infection, HPV genotypes and p53 expression, we respectively employed in situ hybridization (ISH), sequence analysis following short PCR fragment-PCR assay and immunohistochemistry. RESULTS: Of the 23 VC specimens, 11 (48%) had HPV-DNA (detectable by PCR), and 6 (26%) had intranuclear HPV in the upper portion of the squamous epithelium (detectable by ISH). Nine of the 11 PCR-positive specimens showed multiple infections with low- and high-risk HPVs. No HPV-16 infection was detected. Although HPV-6 and HPV-18 were frequently detected by PCR, no HPV could be found in control specimens by ISH. p53 expression was inversely correlated with HPV infection. CONCLUSION: Thus, multiple infections with low- and high-risk HPVs and their rapid replication during hyperkeratinization may participate in the histogenesis of oral VC. Oral VC tumorigenesis may involve the inactivation of p53, which is associated with HPV infection. | |||||
| 書誌情報 |
Pathobiology : journal of immunopathology, molecular and cellular biology 巻 75, 号 4, p. 257-264, 発行日 2008-06 |
|||||
| 出版者 | ||||||
| 出版者 | S. Karger AG | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10152008 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1423-0291 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1077272X | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 18580072 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1159/000132387 | |||||
| 権利 | ||||||
| 権利情報 | Copyright c 2008 S. Karger AG, Basel | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Pathobiology, 75(4), pp.257-264; 2008 | |||||
